Amino Acids and Peptides. XXI. Laminin-Related Peptide Analogs Including Poly(Ethylene Glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis
| Autor: | Machiko Namikawa, Tomohiko Murakami, Koichi Kawasaki, Yuzi Iwai, Yuko Yamashiro, Susumu Yamamoto, Takao Hama, Tadanori Mayumi, Toyohiko Mizuta |
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| Rok vydání: | 1994 |
| Předmět: |
animal structures
Stereochemistry Ratón Molecular Sequence Data Melanoma Experimental Antineoplastic Agents Peptide Inhibitory postsynaptic potential Polyethylene Glycols Mice chemistry.chemical_compound Laminin Drug Discovery Animals Amino Acid Sequence Amino Acids Cytotoxicity chemistry.chemical_classification integumentary system biology General Chemistry General Medicine Amino acid chemistry Biochemistry embryonic structures biology.protein Peptides Glycoprotein Ethylene glycol |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 42:917-921 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | Laminin-related peptides, Tyr-Ile-Gly-Ser-Arg analogs, were prepared and their inhibitory effects on experimental metastasis were examined. Of the amino acids in the Tyr-Ile-Gly-Ser-Arg sequence, L-Arg was very important and Ile was not essential for the inhibitory effect. To obtain a potent inhibitor of metastasis, hybrids of Tyr-Ile-Gly-Ser-Arg-Gly and 2 types of poly(ethylene glycol) were prepared. The inhibitory effects of the hybrids were more potent than that of Tyr-Ile-Gly-Ser-Arg-Gly. |
| Databáze: | OpenAIRE |
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