Surgery plus chemotherapy improves survival of patients with extremity soft tissue leiomyosarcoma and metastasis at presentation
| Autor: | Zhan Wang, Bo Zhang, Jia-Qi Wu, Sheng-Jun Qian |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Leiomyosarcoma
medicine.medical_specialty Multivariate analysis medicine.medical_treatment survival Metastasis 03 medical and health sciences 0302 clinical medicine metastasis at presentation Epidemiology medicine prognostic factor Chemotherapy treatment business.industry Soft tissue medicine.disease Surgery Radiation therapy Oncology 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology business Research Paper Rare disease |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 1973-2015 |
| DOI: | 10.7150/jca.29874 |
| Popis: | Purpose: Extremity soft tissue leiomyosarcoma (LMS) with metastasis is a rare disease with a poor prognosis. The purpose of our study was to define clinical features of extremity soft tissue LMS with metastasis as well as to identify multivariable predictors of survival. Methods: During 1973-2015, 239 patients with metastatic extremity soft tissue LMS were identified from the Surveillance, Epidemiology, and End Results (SEER) program database. The prognostic analysis was performed using the Kaplan-Meier method and a Cox proportional hazards regression model. Results: This group comprised 126 females (52.7%) and 113 males (47.3%), whose ages ranged from 8 to 95 years (median 67 years). The overall survival (OS) and cancer-specific survival (CSS) rates of the entire group at 3 years were 22.6% and 23.4%, respectively. The median OS and CSS were 14.0±1.5 and 15.0±2.3 months, respectively. Multivariate analysis revealed that tumor size >10 cm, no surgery and no chemotherapy were independent risk factors of decreased OS and CSS. Radiotherapy was not significantly associated with OS or CSS. Conclusion: Extremity soft tissue LMS patients who present with metastasis at diagnosis had a poor prognosis. Patients who performed surgery for primary tumors and chemotherapy had a better chance for prolonged survival. |
| Databáze: | OpenAIRE |
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