Carcinoembryonic Antigen Increase in a Patient with Colon Cancer Who Have Achieved Complete Remission and Negative 18F-FDG PET/CT: Don’t Forget the Thyroid!
Autor: | Pauline Hulo, Jaafar Bennouna, Eric Mirallié, Alexandre Lugat, Yann Touchefeu, Delphine Drui, Catherine Ansquer |
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Přispěvatelé: | Bernardo, Elizabeth, Nuclear Oncology (CRCINA-ÉQUIPE 13), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Centre hospitalier universitaire de Nantes (CHU Nantes), Institut des Maladies de l'Appareil Digestif, Université de Nantes (UN), Immunogenic Cell Death and Mesothelioma Therapy (CRCINA-ÉQUIPE 4), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX) |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
endocrine system diseases Colorectal cancer 030209 endocrinology & metabolism [SDV.CAN]Life Sciences [q-bio]/Cancer Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine Carcinoembryonic antigen [SDV.CAN] Life Sciences [q-bio]/Cancer medullary thyroid carcinoma calcitonin Atypia Medicine RC254-282 Tumor marker biology business.industry carcinoembryonic antigen Thyroid Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease 3. Good health medicine.anatomical_structure colon adenocarcinoma Calcitonin 030220 oncology & carcinogenesis biology.protein Adenocarcinoma Radiology business |
Zdroj: | Current Oncology Current Oncology, 2021, 28 (4), pp.2987-2992. ⟨10.3390/curroncol28040261⟩ Current Oncology, Multimed Inc., 2021, 28 (4), pp.2987-2992. ⟨10.3390/curroncol28040261⟩ Current Oncology, Vol 28, Iss 261, Pp 2987-2992 (2021) |
ISSN: | 1198-0052 1718-7729 |
Popis: | Serum carcinoembryonic antigen (CEA) is a tumor marker especially used to follow a patient with colorectal cancer. However, it is non-specific and could be increased in several cancers and some benign conditions. We report the case of a 70-year-old man followed since 2014 for a left colon adenocarcinoma with the persistence of an increased CEA. There was no evidence of recurrence, but a right lobar thyroid nodule without a significantly increased uptake was incidentally discovered on the CT scan of 18F-fluorodeoxyglucose (18F-FDG) PET/CT. We suspected a medullary thyroid carcinoma (MTC) explaining the persistent elevation of CEA. Plasma calcitonin levels were 47 ng/L (N < 10). Fine needle aspiration cytology found atypia of undetermined significance and the patient was reluctant to undergo surgery without any further exploration. We performed a 18F-fluorodihydroxyphenylalanine (18F-FDOPA) PET/CT preoperatively which revealed a punctiform focus of the right thyroid lobe corresponding to a pT1aN1aMxR0 medullary thyroid carcinoma, histopathologically confirmed. This case highlights that despite the potential usefulness of 18F-FDG PET/CT in case of an unknown source of elevated CEA this imaging may be falsely negative as in the case of MTC and should lead to further explorations. |
Databáze: | OpenAIRE |
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