| Popis: |
There are exponential developments in nanotechnology and its medical applications over the past few years, traditional drug delivery systems have been encompassed in smart, stimulus-responsive drug delivery systems. Using the reaction to particular stimuli, known nano-platforms may improve the effectiveness of drug targeting by minimising side effects and the toxicity of payload, which are important factors to enhance patient conformity. Various advanced drug delivery systems are widely used for various interesting structures, such as stimuli-triggered nanoparticles, liposomes. However, these nano-programmes do not have a standardised manufacturing process, toxicity evaluation expertise and clear applicable significance between pre-clinical (diagnostic) and therapeutic studies. A smart drug delivery system (SDDS), a newly developing therapeutic method, is now becoming a traditional drug delivery prototype for particular locations or targets. Drug-targeted delivery (DT) systems sustain the concentration of drugs at required doses in the human body and reduce the necessity for frequent doses. The DT system has some unique features like self-regulation, pre-programming, multi-targeted, timely response control, mapping of targeted drug delivery, response to pH, and spatial targeting. The DT system uses biological membrane modifications in the structure of malicious cells to improve the incorporation or entry of drug-coated nanoparticles into targeted tissues. This device provides a certain amount of the medicinal substance for the longevity of its operation to a targeted region within the human tissue; this increases the effectiveness of the procedure by decreasing the side effects of the drug. Keywords: Smart Drug Delivery System, Microelectromechanical systems, Nanoelectromechanical systems, Nano-carriers, Liposomes. |
