Association of Ki-67 Labelling Index and IL-17A with Pituitary Adenoma

Autor:	Dovile Simonaviciute, Alvita Vilkeviciute, Rasa Liutkeviciene, Ruta Mazetyte, Aurelija Rocyte, I. Gudinaviciene, Loresa Kriauciuniene, Brigita Glebauskiene, Dalia Zaliuniene
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Adenoma Adult Male Pathology medicine.medical_specialty Article Subject endocrine system diseases lcsh:Medicine Pituitary neoplasm General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Young Adult 0302 clinical medicine Blood serum Pituitary adenoma Labelling Medicine Humans Neoplasm Invasiveness Pituitary Neoplasms Aged Retrospective Studies Aged 80 and over General Immunology and Microbiology biology medicine.diagnostic_test business.industry Interleukin-17 lcsh:R Magnetic resonance imaging Lithuania General Medicine Middle Aged medicine.disease Ki-67 Antigen 030220 oncology & carcinogenesis Ki-67 Cavernous sinus biology.protein Immunohistochemistry Female business 030217 neurology & neurosurgery Research Article
Zdroj:	BioMed Research International, Vol 2018 (2018) BioMed Research International
ISSN:	2314-6141 2314-6133
Popis:	The aim of the present study was to determine if the Ki-67 labelling index reflects invasiveness of pituitary adenoma and to evaluate IL-17A concentration in blood serum of pituitary adenoma patients. The study was conducted in the Hospital of Lithuanian University of Health Sciences. All pituitary adenomas were analysed based on magnetic resonance imaging findings. The suprasellar extension and sphenoid sinus invasion by pituitary adenoma were classified according to Hardy classification modified by Wilson. Knosp classification system was used to quantify the invasion of the cavernous sinus. The Ki-67 labelling index was obtained by immunohistochemical analysis with the monoclonal antibody, and serum levels of IL-17A were determined by enzyme-linked immunosorbent assay (ELISA). Sixty-nine PA tissue samples were investigated. Serum levels of IL–17A were determined in 60 patients with PA and 64 control subjects. Analysis revealed statistically significantly higher Ki-67 labelling index in invasive compared to noninvasive pituitary adenomas. Median serum IL-17A level was higher in the pituitary adenoma patients than in the control group. Conclusion. IL-17A might be a significant marker for patients with pituitary adenoma and Ki-67 labelling index in case of invasive pituitary adenomas.
Databáze:	OpenAIRE
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