Pharmacokinetic study of stobadine
| Autor: | D. Mihalová, Mária Ďurišová, Z. Kállay, Katarína Bauerová, P. Bohov, Štefan Bezek, Tomas Trnovec, V. Faberová, V. Koprda, V. Ščasnár, M. Kukan, L. Šortés |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Chemistry
General Medicine Stobadine dipalmitate Pharmacology Antioxidants Gas Chromatography-Mass Spectrometry General Biochemistry Genetics and Molecular Biology Rats Dogs Intestinal Absorption Pharmacokinetics Oral administration Area Under Curve Animals Humans Stobadine dihydrochloride General Pharmacology Toxicology and Pharmaceutics Carbolines Half-Life |
| Zdroj: | Life Sciences. 65:2003-2005 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/s0024-3205(99)00465-8 |
| Popis: | The aim of this paper is to provide a brief overview of most important results of stobadine kinetic studies in rats, dogs, and human volunteers. In these studies, stobadine dihydrochloride and stobadine dipalmitate was used for intravenous and oral administration, respectively. To evaluate kinetic properties of stobadine and its metabolites, TLC, HPLC, GLC, GC-MS, radiometric, and fluorometric methods were developed and used. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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