Micronucleus test in rodent tissues other than liver or erythrocytes: Report of the IWGT working group
| Autor: | Hironao Takasawa, Shuichi Hamada, Takeshi Morita, Mirjam Luijten, Satoru Itoh, Carol Beevers, Wakako Ohyama, Yoshifumi Uno |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pathology medicine.medical_specialty Erythrocytes Colon Health Toxicology and Mutagenesis Urinary Bladder Spleen Biology Mice Clastogen Fetus Genetics medicine Animals Humans Intestinal Mucosa Micronuclei Chromosome-Defective Carcinogen Skin Micronucleus Tests Lung Stomach Mouth Mucosa Anatomy Aneugens Intestinal epithelium Rats medicine.anatomical_structure Animals Newborn Liver Gastric Mucosa Vagina Micronucleus test Female |
| Zdroj: | Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 783:19-22 |
| ISSN: | 1383-5718 |
| Popis: | At the 6th International Workshop on Genotoxicity Testing, the liver micronucleus test (MNT) working group briefly discussed the MNT using tissues other than liver/erythrocytes. Many tissues other than liver/erythrocytes have been studied, primarily for research purposes. They have included the colon and intestinal epithelium, skin, spleen, lung, stomach, bladder, buccal mucosa, vagina, and fetal/neonatal tissues. These tissues were chosen because they were target sites of carcinogens, and/or relevant to a specific route of exposure. Recently, there has been particular focus on the gastrointestinal (GI) tract as it is a contact site associated with high exposure following oral gavage. Furthermore GI tumors are observed with high frequency in human populations. A collaborative study of the rat glandular stomach and colon MNT was conducted in conjunction with a collaborative study of the repeated-dose liver MNT. Based on limited data currently available, the rodent MNT using the glandular stomach and/or colon seems to detect genotoxic carcinogens with GI tract target-organ specificity. The working group concluded that the GI tract MNT would be a promising method to examine clastogenicity or aneugenicity of test chemicals in the stomach and/or colon. Further data will be needed to fully establish the methods, and to identify the sensitivity and specificity of the GI tract MNT. |
| Databáze: | OpenAIRE |
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