SARS-COV2 and P. falciparum common immunodominant regions may explain low COVID-19 incidence in the malaria-endemic belt
| Autor: | Emadeldin He Konozy, Hani M. Babiker, Mitesh J. Borad, Makarim Em Osman, Ritu Pandey, Amina Ia Dirar, Mohamed A. M. Iesa, Mohamed A. Hassan, James J. Mancuso, Nadir Abuzeid, Arwa A. Mohammed |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
030106 microbiology Plasmodium falciparum Biology Microbiology Virus Epitope lcsh:Infectious and parasitic diseases 03 medical and health sciences Immune Epitope Database and Analysis Resource Immune system Antigen Immunity parasitic diseases CD147 receptor medicine lcsh:RC109-216 epitope SARS-CoV-2 medicine.disease biology.organism_classification Virology Homology 030104 developmental biology Infectious Diseases Original Article Malaria |
| Zdroj: | New Microbes and New Infections New Microbes and New Infections, Vol 38, Iss, Pp 100817-(2020) |
| ISSN: | 2052-2975 |
| Popis: | COVID-19 has caused significant morbidity and mortality, and new cases are on the rise globally, yet malaria-endemic areas report statistically significant lower incidences. We identified potential shared targets for an immune response to SARS-CoV-2 by immune determinants shared identities with Plasmodium falciparum using IEDB’s Immune browser tool 9.0. Probable cross-reactivity is suggested through HLA-A*02:01 and subsequent CD8+ T cell activation. The apparent immunodominant epitope conservation between SARS-COV-2 (N and Orf1ab) and P. falciparum thrombospondin-anonymous-related protein (TRAP) may underlie the low COVID-19 incidence in the malaria-endemic zone by providing immunity against virus infection to those previously infected with plasmodium. Additionally, the shared epitopes lie within antigens which aid in the establishment of the P. falciparum invasion to the erythrocytes may hypothesize an alternative route for SARS-CoV-2, though yet to be proven, via erythrocyte CD147 receptor. Highlights • Malaria endemic zones is characterized by apparent low COVID-19 incidences. • Based on experimental and predicted in silico study, possible shared immunodominant epitopes between SARS-CoV2 and P. falciparum antigens were found. • Probable cross-reactivity is hypothesized through HLA-A*02:01 and subsequent CD8+ T cell activation, which may eventually leads to protection against the SARS-COV-2 in the malaria-endemic zones. • The immunodominant epitope conservation between some of the SARS-COV-2 antigens and P. falciparum TRAP may indicate a novel route for the virus. |
| Databáze: | OpenAIRE |
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