The responses to manipulation of extracellular and intracellular calcium are altered in the streptozotocin-diabetic rat colon and ileum
| Autor: | M. E. Parsons, A Molleman, Abigail Forrest |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Agonist medicine.medical_specialty Indoles Time Factors Thapsigargin Nifedipine medicine.drug_class Ileum Calcium-Transporting ATPases Biology digestive system Streptozocin Diabetes Mellitus Experimental Calcium Chloride Colon Ascending chemistry.chemical_compound Internal medicine Diabetes mellitus medicine Extracellular Animals Humans Calcium Signaling Rats Wistar Calcimycin Pharmacology Dose-Response Relationship Drug Muscle Smooth 3-Pyridinecarboxylic acid 1 4-dihydro-2 6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)- Methyl ester Streptozotocin medicine.disease Bay K8644 Small intestine Rats Disease Models Animal Endocrinology medicine.anatomical_structure chemistry Injections Intraperitoneal Muscle Contraction medicine.drug |
| Zdroj: | European Journal of Pharmacology. 509:77-83 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2004.12.029 |
| Popis: | Studies were performed to see if alterations in Ca2+ homeostasis underlie the gastrointestinal motility complications seen in many diabetic patients. Experiments were performed on colonic and ileal tissues taken from streptozotocin-induced diabetic and control rats. Diabetes caused alterations in the responses of the tissues to Ca2+ manipulation but these differed between the colon and ileum. In the colon a small but not significant increase in contractile responses to CaCl2 was observed in diabetic tissues, whereas the responses of the ileum were depressed relative to those of the controls. In contrast, responses of the diabetic ileum to the Ca2+ channel agonist Bay K8644 were greater than those of the controls, whilst the agonist failed to contract the colon. Similarly, the Ca2+-ATPase inhibitors, thapsigargin and cyclopiazonic acid, produced contractions which were greater in diabetic ileal tissues. Thus, alterations in the responses of the diabetic gut to Ca2+ manipulation are complex, and also tissue-specific. |
| Databáze: | OpenAIRE |
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