Experts' opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond
| Autor: | Nikos Prapas, Fabio Facchinetti, Giovanni Monastra, Didier Dewailly, Marialuisa Appetecchia, Lali Pkhaladze, Rosario D'Anna, Cesare Aragona, Eleni Kandaraki, Ali Cenk Ozay, Christophe O. Soulage, Giusy Porcaro, John E. Nestler, Vittorio Unfer, Mariano Bizzarri, Olga Papalou, Artur Wdowiak, Imelda Hernández Marín, Annarita Stringaro, Evanthia Diamanti-Kandarakis, Antonio Simone Laganà, Maria Salome Bezerra Espinola, Zdravko Kamenov, Arturo Bevilacqua, Mario Montanino Oliva, Francesco Orio |
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| Přispěvatelé: | Istituto Nazionale di Fisica Nucleare [Sezione di Roma 1] (INFN), Istituto Nazionale di Fisica Nucleare, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Infertility
endocrine system diseases medicine.medical_treatment [SDV]Life Sciences [q-bio] D-Chiro-Inositol (DCI) Toxicology Bioinformatics 030226 pharmacology & pharmacy Intestinal absorption 03 medical and health sciences Human reproduction Alpha-Lactalbumin (alpha-LA) 0302 clinical medicine Insulin resistance Diabetes mellitus insulin resistance polycystic ovary syndrome (PCOS) medicine Animals Humans D- chiro- inositol (DCI) Expert Testimony Inositol-resistance Myo-Inositol (MI) Non-insulin dependent (type 2) diabetes mellitus (NIDDM) Polycystic Ovary Syndrome (PCOS) absorption Myo- inositol (MI) Pharmacology alpha- lactalbumin (alpha-LA) inositol-resistance non-insulin dependent (type 2) diabetes mellitus (NIDDM) business.industry Polycystic ovary syndrome (PCOS) Reproduction General Medicine medicine.disease Polycystic ovary 3. Good health Diabetes Mellitus Type 2 030220 oncology & carcinogenesis Vitamin B Complex Ovulation induction Female business Inositol Polycystic Ovary Syndrome |
| Zdroj: | Expert opinion on drug metabolism & toxicology Expert opinion on drug metabolism & toxicology, 2020, 16 (3), pp.255--274. ⟨10.1080/17425255.2020.1737675⟩ |
| Popis: | Introduction: This Experts' opinion provides an updated scientific support to gynecologists, obstetricians, endocrinologists, nutritionists, neurologists and general practitioners on the use of Inositols in the therapy of Polycystic Ovary Syndrome (PCOS) and non-insulin dependent (type 2) diabetes mellitus (NIDDM). Areas covered: This paper summarizes the physiology of Myo-Inositol (MI) and D-Chiro-Inositol (DCI), two important molecules present in human organisms, and their therapeutic role, also for treating infertility. Some deep differences between the physiological functions of MI and DCI, as well as their safety and intestinal absorption are discussed. Updates include new evidence on the efficacy exerted in PCOS by the 40:1 MI/DCI ratio, and the innovative approach based on alpha-lactalbumin to overcome the decreased therapeutic efficacy of Inositols in some patients. Expert opinion: The evidence suggests that MI, alone or with DCI in the 40:1 ratio, offers a promising treatment for PCOS and NIDDM. However, additional studies need to evaluate some still unresolved issues, such as the best MI/DCI ratio for treating NIDDM, the potential cost-effectiveness of reduced gonadotropins administration in IVF due to MI treatment, or the benefit of MI supplementation in ovulation induction with clomiphene citrate in PCOS patients. |
| Databáze: | OpenAIRE |
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