Association of NRF2 polymorphism with cholangiocarcinoma prognosis in Thai patients
| Autor: | Auemduan Prawan, Veerapol Kukongviriyapan, Laddawan Senggunprai, Anucha Puapairoj, Ponsilp Zeekpudsa, Narong Khuntikeo, Tueanjai Khunluck |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Genotype Epidemiology NF-E2-Related Factor 2 Single-nucleotide polymorphism Kaplan-Meier Estimate Biology Malignancy Bioinformatics Gastroenterology Polymorphism Single Nucleotide Cholangiocarcinoma Gene Frequency Internal medicine parasitic diseases Genetic variation medicine Biomarkers Tumor Humans Allele frequency Aged Proportional Hazards Models Hazard ratio Public Health Environmental and Occupational Health Middle Aged medicine.disease Prognosis Thailand SNP genotyping Survival Rate Bile Ducts Intrahepatic Oncology Bile Duct Neoplasms Case-Control Studies Adenocarcinoma Female |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 15(1) |
| ISSN: | 2476-762X 1018-3914 |
| Popis: | Cholangiocarcinoma (CCA), a malignancy of biliary duct with a very poor prognosis, is the leading cause of cancer death in countries of the Mekong subregion. Liver fluke infection is the main etiological factor, but genetic variation has been recognized as also important in conferring susceptibility to CCA risk. Nuclear factor (erythroid derived 2)-like 2 (NRF2) is a key transcription factor in detoxification and antioxidant defense. Emerging evidence has demonstrated that genetic polymorphisms in the NRF2 gene may be associated with cancer development. The objectives of this study were to investigate the association of NRF2 genetic polymorphism with CCA risk and to evaluate the influence of the NRF2 genotype on survival time of affected patients. Single nucleotide polymorphisms (SNPs) of the NRF2 gene, including rs6726395: A/G, rs2886161: C/T, rs1806649: C/T, and rs10183914: C/T, were analyzed using TaqMan ® SNP genotyping assays. Among 158 healthy northeastern Thai subjects, the allele frequencies were 41, 62, 94, and 92%, respectively. The correlation of NRF2 SNPs and CCA risk was analyzed in the 158 healthy subjects and 198 CCA patients, using unconditional logistic regression. The results showed that whereas the NRF2 SNPs were not associated with CCA risk (p>0.05), Kaplan-Meier analysis of 88 intrahepatic CCA patients showed median survival time with rs6726395 genotypes of GG and AA/AG to be 344±138 (95%CI: 73-615) days and 172±37 (95%CI: 100-244) days, respectively, (p |
| Databáze: | OpenAIRE |
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