Parathyroid Hormone 1–84 Alters Circulating Vascular Endothelial Growth Factor Levels in Hypoparathyroidism
| Autor: | Chiyuan Zhang, John P. Bilezikian, Laura Anderson, Dinaz Irani, Elizabeth Levy, Natalie E. Cusano, Aline G. Costa, Mishaela R. Rubin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Parathyroidectomy
Adult Vascular Endothelial Growth Factor A medicine.medical_specialty Angiogenesis Hypoparathyroidism Endocrinology Diabetes and Metabolism medicine.medical_treatment Injections Subcutaneous Clinical Biochemistry Parathyroid hormone Neovascularization Physiologic Context (language use) Biochemistry Parathyroid Glands chemistry.chemical_compound Endocrinology Internal medicine medicine Humans Thyroid Neoplasms Aged business.industry Biochemistry (medical) JCEM Online: Brief Reports Middle Aged medicine.disease Recombinant Proteins Vascular endothelial growth factor Vascular endothelial growth factor A medicine.anatomical_structure chemistry Parathyroid Hormone Parathyroid gland Female Menopause business |
| Popis: | Context:We previously reported on four patients treated with PTH(1–84) who recovered from postoperative hypoparathyroidism many years after onset. Because vascular endothelial growth factor (VEGF) has been shown to be necessary for the induction of PTH-mediated angiogenesis, we postulated a possible role for VEGF in the recovery of parathyroid function in these subjects.Objective:Our objective was to measure VEGF levels in subjects with hypoparathyroidism who regained parathyroid gland function and matched controls.Setting and Design:Subjects with hypoparathyroidism who regained parathyroid gland function were each matched to two hypoparathyroid controls by postoperative etiology, age (within 5 y), menopausal status, and duration of hypoparathyroidism. We measured serum VEGF levels at baseline and through 48 months of PTH(1–84) therapy.Results:VEGF levels increased after the initiation of PTH(1–84) therapy for the entire cohort, from 309.7 ± 162 pg/ml at baseline to 380.2 ± 178 pg/ml at 12 months (P = .03). Levels trended downward thereafter. There were no significant differences in VEGF levels between the subjects with recovery of parathyroid function and the matched controls.Conclusions:PTH(1–84) alters serum VEGF levels in subjects with hypoparathyroidism. Additional investigation is necessary to understand the mechanisms by which some subjects with postoperative hypoparathyroidism recover parathyroid gland function. |
| Databáze: | OpenAIRE |
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