| Autor: |
Julian L. Ambrus, Eugene A. Gorzynski, Erwin Neter, C. J. van Oss |
| Rok vydání: |
1972 |
| Předmět: |
|
| Zdroj: |
Immunological Communications. 1:69-75 |
| ISSN: |
0090-0877 |
| DOI: |
10.3109/08820137209022893 |
| Popis: |
Serum specimens obtained from 10 human volunteers immunized intravenously with ethanol soluble common enterobacterial antigen (CA) obtained from E. coli 0111 were tested for opsonizing capacity, utilizing E. coli 07 as indicator organism. Increase in opsonizing activity between pre- and post-immunization specimens was documented in 9 out of 10 subjects, the statistical significance being 0.05 or less in 5 of these individuals. In none of the subjects was the pre-imni-zation serum specimen more effective or as effective as the post-immunization specimen. Absorption of post-immunization serum with human erythrocytes modified by CA from S. typhimurium reduced the opsonizing activity. The specificity of the opsonin response was documented also by the demonstration of enhanced phagocytosis of a rough CA-producing but not a rough CA-negative mutant of S. typhimurium. Although only half of the experiments revealed statistically strongly significant data, all pointed to increased opsonizing capacity due to antibo... |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
