Dietary soy protein benefit in experimental kidney disease is preserved after isoflavone depletion of diet
| Autor: | Evan Nitschmann, Hope A. Weiler, Harold M. Aukema, Neda Bankovic-Calic, Malcolm R. Ogborn |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Renal function Inflammation General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Fibrosis Casein Internal medicine medicine Animals Soy protein Cell Proliferation chemistry.chemical_classification Polycystic Kidney Diseases Caseins Rats Inbred Strains Cholesterol LDL Organ Size Isoflavones medicine.disease Rats Disease Models Animal Endocrinology chemistry Soybean Proteins Dietary Proteins medicine.symptom Oxidation-Reduction Polyunsaturated fatty acid Kidney disease |
| Zdroj: | Experimental Biology and Medicine. 235:1315-1320 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.1258/ebm.2010.010059 |
| Popis: | Soy diet ameliorates renal injury in the Han:SPRD- cy rat. The relative roles of protein, isoflavones and changes in polyunsaturated fatty acid (PUFA) status are not determined. We fed male Han:SPRD- cy heterozygotes casein (C), high isoflavone soy protein (HIS), alcohol-extracted low isoflavone soy protein (LIS) or mixed soy protein diet (MIS). LIS and MIS were associated with a small decrease in animal weight compared with HIS or C. Soy diets preserved normal renal function and reduced relative renal weight (10.9–14.6 g/kg, cf. 23.6, P < 0.001), scores for cystic change (0.168–0.239, cf. 0.386, P < 0.05), fibrosis (0.013–0.015, cf. 0.032, P < 0.05), tissue oxidized LDL content (0.012–0.021, cf. 0.048, P < 0.05), inflammation (8.5–12.9, cf. 31.2, P < 0.05) and epithelial cell proliferation (6.5–13.8, cf. 26.3, P < 0.05). In post hoc testing, LIS produced a greater reduction in relative renal weight, cystic change and epithelial proliferation, whereas HIS produced a significantly greater reduction in oxidized-LDL. Soy diets were associated with increased hepatic content of 18C PUFA ( P < 0.001). LIS and HIS diets were associated with a small increase in body fat content ( P < 0.001). Alcohol-extracted soy protein retains its major protective effects in this model with subtle differences attributable to isoflavones. |
| Databáze: | OpenAIRE |
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