Family history and renin-angiotensin system gene polymorphisms in Chinese patients with type 2 diabetes mellitus
| Autor: | Li-Jun Geng, Wei Ling, Jian-long Xiao, Hai-Lu Zhao, Xiao-Xi Zhang, Yan-Hong Pan, Yan-Mei Huang, Yong-Chao Qiao |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty China obesity hypertension Genotype gene polymorphism type 2 diabetes mellitus Angiotensinogen Observational Study 030209 endocrinology & metabolism Blood Pressure 030204 cardiovascular system & hematology Peptidyl-Dipeptidase A Body Mass Index 03 medical and health sciences 0302 clinical medicine Asian People Gene Frequency Polymorphism (computer science) Diabetes mellitus Internal medicine medicine Humans Family history Genotyping Allele frequency Triglycerides angiotensin converting enzyme family history business.industry Age Factors Type 2 Diabetes Mellitus General Medicine Middle Aged medicine.disease Endocrinology Cross-Sectional Studies Diabetes Mellitus Type 2 ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Female business Body mass index Polymorphism Restriction Fragment Length Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Supplemental Digital Content is available in the text A positive family history is recognized as an important risk factor for type 2 diabetes mellitus (T2DM), but the association of family history with rennin-angiotensin system (RAS) gene polymorphisms has not been reported yet, thus we aim to investigate it. Family history records, clinical and biochemical data were obtained from 1239 T2DM patients. Polymerase chain reaction (PCR) was performed for angiotensin-converting enzyme (ACE) genotyping and PCR-restricted fragment length polymorphism was used for angiotensinogen (AGT) genotyping. Patients with a negative family history had higher level of triglyceride and blood pressure, whereas those with a positive family history showed younger onset age and lower body mass index value (All P |
| Databáze: | OpenAIRE |
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