Intracranial Hemorrhage and Amphetamine Usage
| Autor: | Earl R. Olsen |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adult
Central Nervous System Male Postmortem studies Necrosis Substance-Related Disorders Central nervous system 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine medicine Humans Fibrinoid necrosis Amphetamine Cerebral Hemorrhage medicine.diagnostic_test business.industry Amphetamines medicine.disease Cerebral Angiography medicine.anatomical_structure 030220 oncology & carcinogenesis Anesthesia Cerebritis medicine.symptom Emetics Cardiology and Cardiovascular Medicine business Vasculitis medicine.drug Cerebral angiography |
| Zdroj: | Angiology. 28:464-471 |
| ISSN: | 1940-1574 0003-3197 |
| DOI: | 10.1177/000331977702800704 |
| Popis: | A 25-year-old man died after an intravenous injection of 100 mg of methedrine. Postmortem studies showed visceral congestion, lung edema, pericardial petechiae, centrolobular necrosis of the liver, and diffuse subarachnoid blood, intracranial vasculitis and cerebritis in the absence of aneurysms, arteriovenous malformations or chronic hypertension. A review of the English-language literature produced 3 other cases of fatal amphetamine-induced intracranial hemorrhage and seven nonfatal cases. Some were the result of overdose, others of hypersensitivity. Angiographic evidence suggests that such hemorrhages result from the development of fibrinoid necrosis and the formation of microaneurysms in the small intracerebral vessels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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