Perineural Platelet-Rich Plasma for Diabetic Neuropathic Pain, Could It Make a Difference?

Autor: Abdelraheem Elawamy, Manal Hassanien, Yasmine S. Makarem, Randa A. El Zohne, Ghada Mohamed Abolfadl, Walaa A Khalifa, Emad Zarief Kamel, Al Shimaa Ismael Roushdy
Rok vydání: 2019
Předmět:
Male
Diabetic neuropathy
medicine.medical_treatment
Neural Conduction
Pregabalin
0302 clinical medicine
Diabetic Neuropathies
Pain Measurement
Analgesics
0303 health sciences
Rehabilitation
Thioctic Acid
Platelet-Rich Plasma
General Medicine
Middle Aged
Treatment Outcome
Anesthesia
Vitamin B Complex
Neuropathic pain
Female
Selective Serotonin Reuptake Inhibitors
Adult
medicine.medical_specialty
Visual analogue scale
Glycemic Control
Injections
Hypesthesia
03 medical and health sciences
Sural Nerve
Internal medicine
medicine
Humans
Ulnar Nerve
030304 developmental biology
business.industry
Peroneal Nerve
medicine.disease
Rheumatology
Median Nerve
Clinical trial
Anesthesiology and Pain Medicine
Peripheral neuropathy
Pain Clinics
Diabetes Mellitus
Type 2
Neuralgia
Radial Nerve
Neurology (clinical)
Tibial Nerve
business
030217 neurology & neurosurgery
Zdroj: Pain Medicine. 21:757-765
ISSN: 1526-4637
1526-2375
Popis: ObjectiveTo evaluate the clinical effect of perineural platelet-rich plasma (PRP) injection for pain and numbness alleviation in diabetic peripheral neuropathy (DPN).Study DesignA randomized prospective clinical trial.SettingPain clinic and Rheumatology and Rehabilitation Departments, Assiut University Hospital.MethodsSixty adult patients with type II DM accompanied by DPN of at least six months’ duration were assessed by modified Toronto Clinical Neuropathy Score (mTCNS) and randomly allocated into two groups. Group I underwent ultrasound-guided perineural PRP injection and medical treatment, and Group II received medical treatment only. Patients were followed up at months 1, 3, and 6 with regard to pain and numbness visual analog scale (VAS) and mTCNS scores.ResultsSignificant improvement was recorded in pain and numbness VAS scale scores in group I vs group II (P ≤ 0.001 during the whole study period for both parameters); at the same time, mTCNS improved in group I in comparison with group II with P = 0.01, 0.001, and ConclusionsPerineural PRP injection is an effective therapy for alleviation of diabetic neuropathy pain and numbness and enhancement of peripheral nerve function.
Databáze: OpenAIRE
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