Perineural Platelet-Rich Plasma for Diabetic Neuropathic Pain, Could It Make a Difference?
Autor: | Abdelraheem Elawamy, Manal Hassanien, Yasmine S. Makarem, Randa A. El Zohne, Ghada Mohamed Abolfadl, Walaa A Khalifa, Emad Zarief Kamel, Al Shimaa Ismael Roushdy |
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Rok vydání: | 2019 |
Předmět: |
Male
Diabetic neuropathy medicine.medical_treatment Neural Conduction Pregabalin 0302 clinical medicine Diabetic Neuropathies Pain Measurement Analgesics 0303 health sciences Rehabilitation Thioctic Acid Platelet-Rich Plasma General Medicine Middle Aged Treatment Outcome Anesthesia Vitamin B Complex Neuropathic pain Female Selective Serotonin Reuptake Inhibitors Adult medicine.medical_specialty Visual analogue scale Glycemic Control Injections Hypesthesia 03 medical and health sciences Sural Nerve Internal medicine medicine Humans Ulnar Nerve 030304 developmental biology business.industry Peroneal Nerve medicine.disease Rheumatology Median Nerve Clinical trial Anesthesiology and Pain Medicine Peripheral neuropathy Pain Clinics Diabetes Mellitus Type 2 Neuralgia Radial Nerve Neurology (clinical) Tibial Nerve business 030217 neurology & neurosurgery |
Zdroj: | Pain Medicine. 21:757-765 |
ISSN: | 1526-4637 1526-2375 |
Popis: | ObjectiveTo evaluate the clinical effect of perineural platelet-rich plasma (PRP) injection for pain and numbness alleviation in diabetic peripheral neuropathy (DPN).Study DesignA randomized prospective clinical trial.SettingPain clinic and Rheumatology and Rehabilitation Departments, Assiut University Hospital.MethodsSixty adult patients with type II DM accompanied by DPN of at least six months’ duration were assessed by modified Toronto Clinical Neuropathy Score (mTCNS) and randomly allocated into two groups. Group I underwent ultrasound-guided perineural PRP injection and medical treatment, and Group II received medical treatment only. Patients were followed up at months 1, 3, and 6 with regard to pain and numbness visual analog scale (VAS) and mTCNS scores.ResultsSignificant improvement was recorded in pain and numbness VAS scale scores in group I vs group II (P ≤ 0.001 during the whole study period for both parameters); at the same time, mTCNS improved in group I in comparison with group II with P = 0.01, 0.001, and ConclusionsPerineural PRP injection is an effective therapy for alleviation of diabetic neuropathy pain and numbness and enhancement of peripheral nerve function. |
Databáze: | OpenAIRE |
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