Isosteric ribavirin analogues: Synthesis and antiviral activities

Autor:	Alexander N. Prutkov, Mikhail V. Chudinov, Irina D. Konstantinova, Andrey V. Matveev, Vitaly I. Shvets, Anatoly I. Miroshnikov, Olga S. Smirnova, Nikolay Zhurilo, Lyubov E. Grebenkina, Natalya V. Pulkova
Rok vydání:	2017
Předmět:	Cell Survival viruses Hepacivirus Hepatitis C virus Clinical Biochemistry Pharmaceutical Science Herpesvirus 1 Human 010402 general chemistry medicine.disease_cause 01 natural sciences Biochemistry Antiviral Agents chemistry.chemical_compound Drug Discovery Chlorocebus aethiops Ribavirin Influenza A virus medicine Animals Humans Molecular Biology Vero Cells Cell survival biology 010405 organic chemistry Organic Chemistry virus diseases biochemical phenomena metabolism and nutrition biology.organism_classification Virology digestive system diseases 0104 chemical sciences chemistry Vero cell Molecular Medicine
Zdroj:	Bioorganicmedicinal chemistry letters. 28(1)
ISSN:	1464-3405
Popis:	The novel isosteric ribavirin analogues were synthesized by two different ways. Some of them showed significant antiviral action against hepatitis C virus (HCV), herpes simplex (HCV-1) and influenza A virus comparable to that of ribavirin itself. The data obtained confirm the proposed theory of the ribavirin possible antiviral activity mechanism related with bioisosterism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba805ac12a12aaed9453652a8f711af https://pubmed.ncbi.nlm.nih.gov/29173944 Zobrazit plný text záznamu Full Text from ScienceDirect