Hydrogen sulfide and hepatic lipid metabolism – a critical pairing for liver health
| Autor: | Guangdong Yang, Lingyun Wu, Julie J. Loiselle |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Hydrogen sulfide Bioinformatics 03 medical and health sciences chemistry.chemical_compound Liver disease 0302 clinical medicine Diabetes mellitus Animals Medicine Hydrogen Sulfide Pharmacology Gasotransmitters business.industry Lipid metabolism Metabolism Lipid Metabolism medicine.disease Lipids 3. Good health Metabolic pathway 030104 developmental biology Liver chemistry Hepatic lipid Knockout animal business 030217 neurology & neurosurgery Themed Section: Review Article |
| Zdroj: | Br J Pharmacol |
| ISSN: | 1476-5381 0007-1188 |
| DOI: | 10.1111/bph.14556 |
| Popis: | Hydrogen sulfide (H(2)S) is the most recently recognized gasotransmitter, influencing a wide range of physiological processes. As a critical regulator of metabolism, H(2)S has been suggested to be involved in the pathology of many diseases, particularly obesity, diabetes and cardiovascular disorders. Its involvement in liver health has been brought to light more recently, particularly through knockout animal models, which show severe hepatic lipid accumulation upon ablation of H(2)S metabolic pathways. A complex relationship between H(2)S and lipid metabolism in the liver is emerging, which has significant implications for liver disease establishment and/or progression, regardless of the disease‐causing agent. In this review, we discuss the critical importance of H(2)S in hepatic lipid metabolism. We then describe the animal models so far related with H(2)S and lipid‐associated liver disease, as well as H(2)S‐based treatments available. Finally, we highlight important considerations for future studies and identify areas in which much still remains to be determined. LINKED ARTICLES: This article is part of a themed section on Hydrogen Sulfide in Biology & Medicine. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.4/issuetoc |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text