Trypanocidal and antimicrobial activities of Moquinia kingii
| Autor: | S. de Albuquerque, Marcos José Salvador, Elisandra Cristina Schinor, Izabel Yoko Ito, Diones Aparecida Dias |
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| Rok vydání: | 2004 |
| Předmět: |
Trypanosoma cruzi
Antiprotozoal Agents Pharmaceutical Science Asteraceae Biology Gram-Positive Bacteria Microbiology Inhibitory Concentration 50 chemistry.chemical_compound Anti-Infective Agents Gram-Negative Bacteria Drug Discovery Animals Humans Candida albicans Candida Pharmacology Chloroform Plant Extracts Plant Components Aerial Antimicrobial biology.organism_classification Cynaropicrin Complementary and alternative medicine chemistry Apigenin Molecular Medicine Bacteria Phytotherapy |
| Zdroj: | Phytomedicine. 11:224-229 |
| ISSN: | 0944-7113 |
| Popis: | A chloroform crude extract (aerial part) and two compounds, apigenin (1) and cynaropicrin (2), isolated from Moquinia kingii were evaluated against Trypanosoma cruzi trypomastigotes in vitro. Antimicrobial activity was also screened using twenty-two strains including gram-positive and gram-negative bacteria and the yeasts Candida albicans and C. tropicalis. The chloroform crude extract, fractions and isolated compounds from M. kingii were active for both activities. The IC50 values for trypanocidal activity obtained for cynaropicrin and apigenin were 93.5 microg/ml and 181 microg/ml, respectively, while the minimum inhibitory concentrations (MICs) varied from 100 microg/ml to 2500 microg/ml, against the strains of bacteria and yeasts evaluated. |
| Databáze: | OpenAIRE |
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