Y chromosome polymorphisms may contribute to an increased risk of male-induced unexplained recurrent miscarriage
| Autor: | Dan-Dan Quan, Gang Li, Jun-Hua Fang, Wang Yan, Man-Zhen Zuo, Ping-Ping Peng, Lu Huang, Hai-Rong Li |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male group D/G Logistic regression Biochemistry Miscarriage 0302 clinical medicine Pregnancy Risk Factors Recurrent miscarriage Research Articles unexplained recurrent miscarriage Genetics 030219 obstetrics & reproductive medicine Gestational age 1/9/16qh+ inv(9) Female Research Article Adult Y chromosome polymorphism medicine.medical_specialty Abortion Habitual China Biophysics Gestational Age Biology Y chromosome 03 medical and health sciences medicine Humans Molecular Biology Infertility Male Gynecology Chromosomes Human Y Polymorphism Genetic Chromosome Cell Biology medicine.disease Human genetics Chromosome Banding 030104 developmental biology Logistic Models Karyotyping Yqh+ Yqh |
| Zdroj: | Bioscience Reports |
| ISSN: | 1573-4935 |
| Popis: | The present study aims to explore the relationship between the Y chromosome polymorphisms (1qh+, inv(9), 9qh+, 16qh+, group D/G, Yqh– and Yqh+) and the risk of unexplained recurrent miscarriage (URM). A total of 507 couples with URM were recruited as case group and 465 healthy couples as control group. The Y chromosome polymorphisms of the male individuals were analysed with the G-banding technique, and the results of the chromosome G-banding analysis were determined using the International Naming Standards of Human Genetics (ISCN). Logistic regression analysis was used to analyse the risk factors for URM. The detection rate of Y chromosome polymorphisms in the case group (12.03%) was higher than that in the control group (2.15%). Y chromosome polymorphisms were detected at significantly higher rates in the case group than in the control group. Using the normal Y chromosomes in individuals of the case group as reference, the partners of their counterparts were more likely to experience miscarriage. The couples who were Y chromosome-polymorphism carriers had shorter gestational age, increased frequency of URM and longer average interval between pregnancies. The results of logistic regression analysis revealed that Y chromosome polymorphisms, shorter gestational age, a higher frequency of miscarriage and longer pregnancy interval were independent risk factors for URM. Y chromosome polymorphisms may be associated with the risk of URM and may play an important role in the development of URM. |
| Databáze: | OpenAIRE |
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