Loss of chromosome Y in blood, but not in brain, of suicide completers

Autor: Ikuo Otsuka, Motonori Takahashi, Tadasu Horai, Shuken Boku, Ichiro Sora, Akitoyo Hishimoto, Takeshi Izumi, Osamu Shirakawa, Atsushi Kimura, Yasuhiro Ueno, Satoshi Okazaki
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Physiology
lcsh:Medicine
Pathology and Laboratory Medicine
Habits
Mathematical and Statistical Techniques
Medicine and Health Sciences
Smoking Habits
Prefrontal cortex
lcsh:Science
AMELX
X chromosome
Sex Chromosomes
Multidisciplinary
Chromosome Biology
Brain
X Chromosomes
Y Chromosomes
Pathophysiology
Body Fluids
Suicide
Blood
medicine.anatomical_structure
Physical Sciences
Regression Analysis
Chromosome Deletion
Anatomy
Statistics (Mathematics)
Research Article
medicine.medical_specialty
Prefrontal Cortex
Single-nucleotide polymorphism
Research and Analysis Methods
Chromosomes
03 medical and health sciences
Internal medicine
Mental Health and Psychiatry
medicine
Humans
Statistical Methods
Behavior
Chromosomes
Human
Y
business.industry
lcsh:R
Biology and Life Sciences
Cell Biology
Odds ratio
Confidence interval
Dorsolateral prefrontal cortex
030104 developmental biology
Endocrinology
lcsh:Q
business
Mathematics
Zdroj: PLoS ONE, Vol 13, Iss 1, p e0190667 (2018)
PLoS ONE
ISSN: 1932-6203
Popis: Men have a higher rate of completed suicide than women, which suggests that sex chromosome abnormalities may be related to the pathophysiology of suicide. Recent studies have found an aberrant loss of chromosome Y (LOY) in various diseases; however, no study has investigated whether there is an association between LOY and suicide. The purpose of this study was to determine whether LOY occurs in men who completed suicide. Our study consisted of 286 male Japanese subjects comprised of 140 suicide completers without severe physical illness (130 post-mortem samples of peripheral blood and 10 brains) and 146 age-matched control subjects (130 peripheral blood samples from healthy individuals and 16 post-mortem brains). LOY was measured as the chromosome Y/chromosome X ratio of the fluorescent signal of co-amplified short sequences from the Y-X homologous amelogenin genes (AMELY and AMELX). Regression analyses showed that LOY in the blood of suicide completers was significantly more frequent than that found in controls (odds ratio = 3.50, 95% confidence interval = 1.21–10.10), but not in the dorsolateral prefrontal cortex (DLPFC) region of brain. Normal age-dependent LOY in blood was found in healthy controls (r = -0.353, p < 0.001), which was not seen in suicide completers (r = -0.119, p = 0.177). DLPFC tissue had age-dependent LOY (B = -0.002, p = 0.015), which was independent of phenotype. To our knowledge, this is the first study demonstrating that LOY in blood is associated with suicide completion. In addition, our findings are the first to also indicate that age-dependent LOY may occur not only in blood, but also in specific brain regions.
Databáze: OpenAIRE
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