Interleukin-18 as a Predictor of Future Events in Patients With Acute Coronary Syndromes
| Autor: | Anita Persson, Johannes Hulthe, Thomas Karlsson, Lillemor Mattsson Hultén, Olov Wiklund, Johan Herlitz, Marianne Hartford, Kenneth Caidahl |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Acute coronary syndrome medicine.medical_specialty Time Factors Myocardial Infarction Risk Factors Internal medicine medicine Humans In patient Myocardial infarction Acute Coronary Syndrome Aged Heart Failure Sweden biology Vascular disease business.industry C-reactive protein Interleukin-18 Middle Aged Prognosis medicine.disease Confidence interval Surgery Heart failure biology.protein Cardiology Female Interleukin 18 Inflammation Mediators Cardiology and Cardiovascular Medicine business |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 30:2039-2046 |
| ISSN: | 1524-4636 1079-5642 |
| Popis: | Objective— The aim of this study was to assess the short- and long-term prognostic significance of interleukin-18 (IL-18) levels in patients with acute coronary syndromes (ACS). Methods and Results— In patients hospitalized with ACS (median age, 66 years; 30% females), we evaluated associations of serum IL-18 levels from day 1 (n=1261) with the short- (P =0.002). Long-term, cardiovascular mortality was univariately related to IL-18, and the adjusted relation between noncardiovascular mortality and IL-18 was highly significant (HR, 1.36; 95% confidence interval, 1.11 to 1.67; P =0.003). IL-18 independently predicted CHF, MI, and cardiovascular death/CHF/MI in both the short and long term. Measurements from day 1 of ACS and 3 months after ACS had a similar power to predict late outcome. Conclusion— The addition of the measurement of IL-18 to clinical variables improved the prediction of risk of all-cause and noncardiovascular mortality. The association between IL-18 and noncardiovascular mortality is intriguing and warrants further study. |
| Databáze: | OpenAIRE |
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