Genomic characterisation of Salmonella enterica serovar Wangata isolates obtained from different sources reveals low genomic diversity

Autor: Siobhan M. Mor, Julie Collins, Grant A. Hill-Cawthorne, Kelly M. J. Simpson, James E. Flint, Michael P. Ward, Moataz Abd El Ghany
Rok vydání: 2019
Předmět:
0301 basic medicine
Serotype
Bacterial Diseases
Salmonella
Pathogenesis
Wildlife
medicine.disease_cause
Pathology and Laboratory Medicine
Medicine and Health Sciences
Pathogen
Phylogeny
Genetics
Multidisciplinary
Salmonella enterica
Eukaryota
Genomics
Bacterial Pathogens
Infectious Diseases
Medical Microbiology
Salmonella Typhimurium
Medicine
New South Wales
Pathogens
Research Article
Science
Animal Types
030106 microbiology
Virulence
Biology
Serogroup
Microbiology
03 medical and health sciences
Antibiotic resistance
Enterobacteriaceae
Microbial Control
medicine
Animals
Humans
Microbial Pathogens
Pharmacology
Whole Genome Sequencing
Bacteria
Organisms
Outbreak
Genetic Variation
Biology and Life Sciences
Computational Biology
Comparative Genomics
biology.organism_classification
Genome Analysis
030104 developmental biology
Antimicrobial Resistance
Zoology
Genome
Bacterial
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 2, p e0229697 (2020)
ISSN: 1932-6203
Popis: Salmonella enterica serovar Wangata is an important pathogen in New South Wales (NSW), Australia. The incidence of S. Wangata is increasing and transmission is suspected to be via a non-food source. A recent outbreak investigation of sources of S. Wangata recovered isolates from humans, domestic animals, wildlife and the environment. Here, we extend that investigation by characterising and describing the genomic determinates of these isolates. We found that Australian S. Wangata isolates from different sources exhibited similar virulence and antimicrobial resistance gene profiles. There were no major genomic differences between isolates obtained from different geographical regions within Australia or from different host species. In addition, we found evidence (low number of SNPs and identical virulence gene profiles) suggestive of an international transmission event between Australia and the United Kingdom. This study supports the hypothesis that S. Wangata is shared between different hosts in NSW, Australia and provides strong justification for the continued use of genomic surveillance of Salmonella.
Databáze: OpenAIRE
Externí odkaz: