Analysis and clinical relevance of human leukocyte antigen class I, heavy chain, and beta2-microglobulin downregulation in breast cancer
| Autor: | Maria Pia Pistillo, Paolo Bruzzi, Lucia Del Mastro, Simona Pastorino, Stefania Laurent, Giuseppe Balbi, Anna Morabito, Sandra Salvi, Gennaro Pasciucco, Franca Carli, Mauro Truini, Beatrice Dozin |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Lymphovascular invasion Immunology Down-Regulation Breast Neoplasms Human leukocyte antigen Kaplan-Meier Estimate Breast cancer Downregulation and upregulation HLA Antigens Immunology and Allergy Medicine Humans Aged Aged 80 and over business.industry Beta-2 microglobulin Histocompatibility Antigens Class I General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry Cancer cell Cancer research Tumor necrosis factor alpha Female business beta 2-Microglobulin Follow-Up Studies |
| Zdroj: | Human immunology. 70(7) |
| ISSN: | 1879-1166 |
| Popis: | Investigation is lacking regarding the clinical impact of human leukocyte antigen (HLA) class I downregulation in breast cancer and results are inconsistent. In this study, we investigated the expression of HLA class I, the heavy chain, and beta2-microglobulin (beta2-m) by immunohistochemistry in 67 breast carcinomas (BC) and correlated results with clinical-pathologic parameters and patient outcomes. Seventy-six percent of BC were downregulated for HLA class I, whereas downregulation of heavy chain and beta2-m was observed in 57 and 46% of BC, respectively. A significant association existed between the absence of tumor necrosis and downregulation of class I and beta2-m and between the absence of lymphovascular invasion and patient's age and downregulated class I and heavy chain, respectively. Among the lymph node-positive BC patients, a significantly improved overall survival was observed in those showing beta2-m downregulation compared with patients with normal beta2-m. This result may correlate with the role of beta2-m in regulating cancer cell growth. |
| Databáze: | OpenAIRE |
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