A new predictor of in-stent restenosis in patients undergoing elective percutaneous coronary İntervention: triglyceride glucose İndex
| Autor: | Nafi Dogan, Muhsin Kalyoncuoglu, Alev Arat Ozkan, Ayşem Kaya, Aziz Tevfik Gürmen, Yasin Yuksel |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Triglyceride glucose index business.industry medicine.medical_treatment Case-control study Percutaneous coronary intervention Stent medicine.disease restenosis chemistry.chemical_compound Restenosis chemistry RC666-701 Internal medicine Diabetes mellitus Conventional PCI medicine Cardiology Diseases of the circulatory (Cardiovascular) system glucose Risk factor Cardiology and Cardiovascular Medicine business triglycerides |
| Zdroj: | International Journal of the Cardiovascular Academy, Vol 7, Iss 2, Pp 50-54 (2021) |
| ISSN: | 2405-8181 |
| DOI: | 10.4103/ijca.ijca_15_21 |
| Popis: | Objective: This study aimed to investigate whether triglyceride glucose (TyG) index predicts the development of in-stent restenosis (ISR) in patients undergoing percutaneous coronary intervention (PCI) for de novo lesions. Materials and Methods: This was a prospective case controlled study and includes 124 patients with a mean age of 57 ± 9.1. Control coronary angiography was performed in all patients enrolled in the study 6–12 months after the PCI. Blood sample triglycerides (TGs) and blood glucose concentrations were collected after at least 8 h of fasting. The TyG index was calculated as follows: log (serum TGs [mg/dL] × plasma glucose [mg/dL]/2). The study cohort was divided into two groups as those with and without restenosis. Angiographically, stent restenosis, defined as the presence of ≥50% diameter narrowing either within the stent or within 5 mm proximally or distally to the stent margin. Results: The median follow-up time was 7.17 months (±2.01). Forty-eight patients (38.7%) had restenosis. Patients with ISR had more diabetes (P < 0.01) and CAD (P = 0.03). These also had higher TyG index (P = 0.04) and less drug-eluting stent implantation (P = 0.04). Diabetes (odds ratio [OR]: 1.927, P = 0.03), stent type (OR: 0.342, P = 0.02), and TyG index (OR: 4.144, P = 0.01) significantly predicted ISR. The receiver operating characteristics curve analysis revealed a cutoff value of TyG index >4.71 predicts the development of ISR. Conclusion: A TyG above 4.71 was found a risk factor for ISR during 1-year follow-up period after index elective PCI. |
| Databáze: | OpenAIRE |
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