Dosing strategy based on prevailing aminoglycoside minimum inhibitory concentration in India: Evidence and issues
| Autor: | Bhaskar Narayan Chaudhuri, Balaji Veeraraghavan, Indranil Roy, Ramya Iyadurai, Sangeeta Joshi, Priscilla Rupali, D.S. Chitnis, Dhole Tapan, Camilla Rodrigues, Agila Kumari Pragasam, Abi Manesh |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) 030106 microbiology Immunology lcsh:QR1-502 India Microbial Sensitivity Tests Pharmacology medicine.disease_cause Microbiology Clinical success lcsh:Microbiology 03 medical and health sciences Minimum inhibitory concentration 0302 clinical medicine Immunology and Microbiology (miscellaneous) Enterobacteriaceae Immunology and Allergy Medicine Humans Pseudomonas Infections EUCAST 030212 general & internal medicine Dosing General Immunology and Microbiology business.industry Pseudomonas aeruginosa Aminoglycoside Broth microdilution Dosing regimen Enterobacteriaceae Infections dosing Anti-Bacterial Agents Infectious Diseases Aminoglycosides Amikacin Minimum Inhibitory Concentration CLSI business medicine.drug |
| Zdroj: | Indian Journal of Medical Microbiology, Vol 35, Iss 4, Pp 585-587 (2017) |
| ISSN: | 1998-3646 |
| Popis: | Aminoglycosides are important agents used for treating drug-resistant infections. The current dosing regimen of aminoglycosides does not achieve sufficient serum level concentration for the infected bacterial pathogen interpreted as susceptible based on laboratory testing. Minimum inhibitory concentration was determined for nearly 2000 isolates of Enterobacteriaceae and Pseudomonas aeruginosa by broth microdilution method. Results were interpreted based on CLSI and EUCAST interpretative criteria and the inconsistencies in the susceptibility profile were noted. This study provides insights into the inconsistencies existing in the laboratory interpretation and the corresponding clinical success rates. This urges the need for revising clinical breakpoints for amikacin, to resolve under dosing leading to clinical failure. |
| Databáze: | OpenAIRE |
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