Changes in volume and incorporation of [35S]- or [3H]-methionine in the amygdala before and after puberty in male and female mice
| Autor: | Pamela C. B. MacKINNON |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
medicine.medical_specialty Biology Tritium Hippocampus Amygdala Basal Ganglia Cerebral Ventricles Mice Sexual Behavior Animal chemistry.chemical_compound Methionine Thalamus Relative Volume Internal medicine Sulfur Isotopes medicine Animals Molecular Biology Cell Nucleus General Neuroscience Putamen Fornix Volume measurements medicine.anatomical_structure Endocrinology chemistry Brain size Autoradiography Female Neurology (clinical) Nucleus Developmental Biology |
| Zdroj: | Brain Research. 50:115-123 |
| ISSN: | 0006-8993 |
| Popis: | (1) Low and high resolution autoradiographs were made from serial sections through the brains of immature (15-day-old) and adult (60–76-day-old) male and female littermate mice, previously injected with either [35S]- or [3H]methionine. (2) Volume measurements were made of the brain (within certain defined limits), of the bed nucleus of the fornix (NF) and of the lateral nucleus of the amygdala (LNA), using the low resolution autoradiographs. The brain volume was similar in immature and adult animals. The volume of the NF was found to be significantly larger, and the LNA smaller, in adult animals. (3) The relative volumes of cell nuclei, and non-nuclear tissue, were measured in the NF, LNA and putamen. The relative volumes of both structures were similar in the LNA and putamen for both immature and adult animals. The relative volume of non-nuclear tissue was increased in the NF in adult as compared with immature animals, probably as a result of myelination. (4) Grain density ratios were measured in the NF and LNA and related to those of the putamen. The ratios for the NF/putamen were similar in immature and adult animals. Ratios for the LNA/putamen were similar in immature animals of both sexes and in adult females, but adult males showed significantly higher ratios. (5) It is possible that the smaller volume of the LNA, and the sexual difference in uptake of methionine seen in adult animals, may be associated with the changes in reproductive activity which occur at puberty. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|