Protein-Based Fiber Materials in Medicine: A Review
Autor: | Guowei Lin, Xiao Hu, Robert Moore, Thomas Mulderig, Vincent Beachley, Kelsey G. DeFrates, Julia Borgesi |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Materials science
Fabrication medicine Biocompatibility General Chemical Engineering biomaterials fabrication Nanotechnology wound healing 02 engineering and technology Review 010402 general chemistry 01 natural sciences lcsh:Chemistry Tissue engineering nanofibers General Materials Science Fiber Spinning technology industry and agriculture 021001 nanoscience & nanotechnology Electrospinning 0104 chemical sciences SILK lcsh:QD1-999 Nanofiber tissue engineering drug delivery 0210 nano-technology protein |
Zdroj: | Nanomaterials Nanomaterials, Vol 8, Iss 7, p 457 (2018) |
ISSN: | 2079-4991 |
Popis: | Fibrous materials have garnered much interest in the field of biomedical engineering due to their high surface-area-to-volume ratio, porosity, and tunability. Specifically, in the field of tissue engineering, fiber meshes have been used to create biomimetic nanostructures that allow for cell attachment, migration, and proliferation, to promote tissue regeneration and wound healing, as well as controllable drug delivery. In addition to the properties of conventional, synthetic polymer fibers, fibers made from natural polymers, such as proteins, can exhibit enhanced biocompatibility, bioactivity, and biodegradability. Of these proteins, keratin, collagen, silk, elastin, zein, and soy are some the most common used in fiber fabrication. The specific capabilities of these materials have been shown to vary based on their physical properties, as well as their fabrication method. To date, such fabrication methods include electrospinning, wet/dry jet spinning, dry spinning, centrifugal spinning, solution blowing, self-assembly, phase separation, and drawing. This review serves to provide a basic knowledge of these commonly utilized proteins and methods, as well as the fabricated fibers’ applications in biomedical research. |
Databáze: | OpenAIRE |
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