Increased rate of complications in myasthenia gravis patients following hip and knee arthroplasty: a nationwide database study in the PearlDiver Database on 257,707 patients
| Autor: | Fernando L. Sanchez, Bailey J. Ross, Ian Savage-Elliott, William F. Sherman, Victor J. Wu, Sione A. Ofa |
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| Rok vydání: | 2021 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty Databases Factual Arthroplasty Replacement Hip medicine.medical_treatment MEDLINE Total knee arthroplasty Cohort Studies 03 medical and health sciences Postoperative Complications 0302 clinical medicine Elderly population Myasthenia Gravis medicine Humans Orthopedics and Sports Medicine 030212 general & internal medicine Arthroplasty Replacement Knee Aged Retrospective Studies Orthopedic surgery Aged 80 and over 030222 orthopedics business.industry Nationwide database General Medicine Middle Aged musculoskeletal system medicine.disease Arthroplasty Myasthenia gravis Surgery surgical procedures operative Female business RD701-811 Research Article Total hip arthroplasty |
| Zdroj: | Acta Orthopaedica article-version (VoR) Version of Record Acta Orthopaedica, Vol 92, Iss 2, Pp 176-181 (2021) |
| DOI: | 10.6084/m9.figshare.13516277 |
| Popis: | Background and purpose ��� The increasing prevalence of total hip arthroplasty (THA) and total knee arthroplasty (TKA) within the growing elderly population is translating into a larger number of patients with neuromuscular conditions such as myasthenia gravis (MG) receiving arthroplasty. We compared systemic and joint complications following a THA or TKA between patients with MG and patients without MG. Patients and methods ��� Patient records were queried from PearlDiver (Pearl Diver Inc, Fort Wayne, IN, USA), an administrative claims database, using ICD-9/ICD-10 and Current Procedural Terminology codes. In-hospital and 90-day post-discharge rates of systemic and joint complications were compared between the 2 cohorts. Results ��� 372 patients with MG and 249,428 patients without MG who received a THA or TKA were included in the study. At 90 days post-discharge, MG patients exhibited exhibited between 1.6 and 15% higher rates of systemic complications, including cerebrovascular event, pneumonia, respiratory failure, sepsis, myocardial infarction, acute renal failure, anemia, and deep vein thrombosis (all p < 0.001). The same results were also found during the in-hospital time period. 90-day incidence of aseptic loosening was the only joint complication with significantly increased odds risk for the MG cohort (OR 5; 95% CI 2���12). Interpretation ��� Patients with MG exhibited significantly higher risk for multiple systemic complications during the index hospital stay and in the acute post-discharge setting. |
| Databáze: | OpenAIRE |
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