Quantitative OCT angiography of optic nerve head blood flow
| Autor: | Bernhard Baumann, Chen D. Lu, Yali Jia, John C. Morrison, James G. Fujimoto, Jason Tokayer, Ou Tan, David Huang, WooJhon Choi, Lorinna Lombardi |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
genetic structures Glaucoma 01 natural sciences Microcirculation 010309 optics 03 medical and health sciences 0302 clinical medicine Optical coherence tomography Ophthalmology 0103 physical sciences ocis:(170.4500) Optical coherence tomography ocis:(170.4470) Ophthalmology medicine medicine.diagnostic_test business.industry Blood flow medicine.disease eye diseases Atomic and Molecular Physics and Optics 3. Good health medicine.anatomical_structure Ophthalmology Applications Angiography 030221 ophthalmology & optometry Optic nerve sense organs ocis:(170.3880) Medical and biological imaging business Perfusion Biotechnology Optic disc |
| Zdroj: | Biomedical Optics Express |
| ISSN: | 2156-7085 |
| DOI: | 10.1364/boe.3.003127 |
| Popis: | Optic nerve head (ONH) blood flow may be associated with glaucoma development. A reliable method to quantify ONH blood flow could provide insight into the vascular component of glaucoma pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), we developed a new 3D angiography algorithm called split-spectrum amplitude-decorrelation angiography (SSADA) for imaging ONH microcirculation. In this study, a method to quantify SSADA results was developed and used to detect ONH perfusion changes in early glaucoma. En face maximum projection was used to obtain 2D disc angiograms, from which the average decorrelation values (flow index) and the percentage area occupied by vessels (vessel density) were computed from the optic disc and a selected region within it. Preperimetric glaucoma patients had significant reductions of ONH perfusion compared to normals. This pilot study indicates OCT angiography can detect the abnormalities of ONH perfusion and has the potential to reveal the ONH blood flow mechanism related to glaucoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|