Current prospects of successful therapeutic procedures in advanced stage melanoma – the short review

Autor: Izabela Czyżewska, Piotr Michał Jarosz, Patrycja Wiśniewska
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Education, Health and Sport, Vol 10, Iss 8, Pp 308-312 (2020)
ISSN: 2391-8306
Popis: Jarosz Piotr, Wiśniewska Patrycja, Czyżewska Izabela. Current prospects of successful therapeutic procedures in advanced stage melanoma – the short review. Journal of Education, Health and Sport.2020;10(8):308-312. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.08.036 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.08.036 https://zenodo.org/record/3994915 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.08.2020. Revised: 05.08.2020. Accepted: 21.08.2020. Current prospects of successful therapeutic procedures in advanced stage melanoma – the short review Piotr M. Jarosz1, Patrycja Wiśniewska2, Izabela Czyżewska2 1 Faculty of Medicine, Medical University of Lublin, Chodźki Street 19, 20-093 Lublin, Poland 2Faculty of Pharmacy with Medical Analytics Division, Medical University of Lublin, Chodźki Street 4a, 20-093 Lublin, Poland Piotr M. Jarosz; pjarosz196@gmail.com; ORCID: 0000-0003-0489-2600; Patrycja Wiśniewska; paatrycja.wisniewska@gmail.com; ORCID: 0000-0001-5026-4045; Izabela Czyżewska; iza_czyzewska@wp.pl; ORCID: 0000-0002-4915-4559; Summary: Introduction and purpose: Melanoma is the most aggressive form of skin cancer with a rapid course of disease in advanced stage according to the melanoma staging system of the American Joint Committee on Cancer (AJCC). Its morbidity has increased from 20thcentury. Intermittent sun exposure, age and skin phenotype are included into main risk factors of melanoma. The gold standard in diagnostic and therapeutic procedures is the naevus excisional biopsy associated with histopathology examination. The knowledge about immune system and melanoma biology have enabled therapeutic advantages, such as immunotherapy and molecular target therapy. Objective:To review currently available data on PubMed about current prospects of successful therapeutic procedures in advanced stage melanoma. A brief description of the state of knowledge: A systemic complementary therapy and non-specific immunotherapy are used for treatment advanced-stage-melanoma patients. Current knowledge has enabled an implementation of molecular target therapy in advanced stage melanoma. Evidence based science has yielded promising results and it has included these therapies to the clinical practice, especially molecular target therapy and immunotherapy as well. BRAF inhibitors including vemurafenib, dabrafenib and MEK inhibitors including trametinib are considered to medicaments, that have molecular mechanism of action. Nivolumab, pembrolizumab, ipilimumab are examples of monoclonal antibodies, which are used as an immunotherapy. Conclusions:Excisional biopsy associated with histopathology have been an essential element in therapeutic and diagnostic procedures. Current achievements of medicine sciences have shed light on biology and pathogenesis highlighting the role of immunotherapy and molecular target treatment as well. Key words: melanoma; naevus; ultraviolet radiation; molecular target treatment; immunotherapy
Databáze: OpenAIRE
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