Predictive value of a reduction in the level of high-density lipoprotein-cholesterol in patients with non-small-cell lung cancer undergoing radical resection and adjuvant chemotherapy: a retrospective observational study

Autor: Ting Zhou, Kangmei Zeng, Li Zhang, Zhonghan Zhang, Hongyun Zhao, Jia-Xin Cao, Wen-Juan Ma, Fan Luo, Yunpeng Yang, Feiteng Lu, Yan Huang, Su-Xia Lin
Rok vydání: 2021
Předmět:
Male
Lung Neoplasms
Apolipoprotein B
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Clinical Biochemistry
Gastroenterology
chemistry.chemical_compound
Endocrinology
High-density lipoprotein
Carcinoma
Non-Small-Cell Lung
Stage (cooking)
Pneumonectomy
Nutritional diseases. Deficiency diseases
Univariate analysis
High-density lipoprotein-cholesterol
biology
Fasting
Middle Aged
Prognosis
Chemotherapy
Adjuvant
Apolipoprotein B-100
Female
lipids (amino acids
peptides
and proteins)
Adult
medicine.medical_specialty
RC620-627
Disease-free survival
Internal medicine
medicine
Humans
Lung cancer
Triglycerides
Aged
Neoplasm Staging
Retrospective Studies
Chemotherapy
Apolipoprotein A-I
Cholesterol
business.industry
Research
Cholesterol
HDL
Biochemistry (medical)
Cancer
Cholesterol
LDL
medicine.disease
Adjuvant chemotherapy
chemistry
biology.protein
business
Non-small-cell lung cancer
Zdroj: Lipids in Health and Disease, Vol 20, Iss 1, Pp 1-14 (2021)
Lipids in Health and Disease
ISSN: 1476-511X
DOI: 10.1186/s12944-021-01538-1
Popis: Background Cancer patients often exhibit chemotherapy-associated changes in serum lipid profiles, however, their prognostic value before and after adjuvant chemotherapy on survival among non-small-cell lung cancer (NSCLC) patients is unknown. Methods NSCLC patients undergoing radical resection and subsequent adjuvant chemotherapy from 2013 to 2017 at Sun Yat-sen University Cancer Center were retrospectively reviewed. Fasted serum lipid levels were measured before and after chemotherapy. The optimal lipid cut-off values at baseline and fluctuation were determined using X-tile™. The fluctuations in serum lipid levels and disease-free survival (DFS) were assessed. Results Serum cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), triglyceride, apolipoprotein (Apo) A-I, and ApoB all significantly increased after adjuvant chemotherapy. X-tile determined 1.52 mmol/L of HDL-C and 0.74 g/L of ApoB as the optimal cut-off values before chemotherapy. Patients with HDL-C ≥ 1.52 mmol/L (median DFS: not reached vs. 26.30 months, P = 0.0005) and a decreased HDL-C level after adjuvant chemotherapy (median DFS: 80.43 vs. 26.12 months, P = 0.0204) had a longer DFS. An HDL-C level that increased by ≥ 0.32 mmol/L after chemotherapy indicated a worse DFS. A high baseline ApoB level were associated with a superior DFS. In the univariate analysis and the multivariate Cox analyses, a high baseline HDL-C level and a HDL-C reduction after adjuvant chemotherapy were independent indicators for superior DFS. High baseline HDL-C was related to N0-1 stage (χ2 = 6.413, P = 0.011), and HDL-C fluctuation was significantly correlated with specific chemotherapy regimens (χ2 = 5.002, P = 0.025). Conclusions Adjuvant chemotherapy increased various lipid levels in resected NSCLC patients. A higher HDL-C level before chemotherapy and a reduced HDL-C level after adjuvant chemotherapy were independent predictors of longer DFS in patients with curable NSCLC.
Databáze: OpenAIRE
Externí odkaz: