Impact of the seven-valent pneumococcal conjugate vaccination (PCV7) programme on childhood hospital admissions for bacterial pneumonia and empyema in England: national time-trends study, 1997-2008
Autor: | Joanna Murray, Alex Bottle, Elizabeth Koshy, Mike Sharland, Sonia Saxena |
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Rok vydání: | 2010 |
Předmět: |
Male
Pulmonary and Respiratory Medicine Pediatrics medicine.medical_specialty Adolescent Population medicine.disease_cause State Medicine Pneumococcal Vaccines Age Distribution Streptococcus pneumoniae Pneumonia Bacterial Humans Medicine Child education Respiratory Tract Infections Empyema Pleural education.field_of_study Vaccines Conjugate Immunization Programs business.industry Respiratory disease Infant Newborn Bacterial pneumonia Infant medicine.disease Empyema respiratory tract diseases Hospitalization Vaccination Pneumonia England El Niño Child Preschool Female business |
Zdroj: | Thorax. 65:770-774 |
ISSN: | 0040-6376 |
DOI: | 10.1136/thx.2010.137802 |
Popis: | Childhood bacterial pneumonia and empyema rates have reportedly increased in recent years in Europe. In September 2006 the seven-valent pneumococcal conjugate vaccination (PCV7) was introduced to the childhood national immunisation programme in England following a successful PCV7 campaign in the USA. The aim of this study was to report national time trends in hospital admissions for childhood bacterial pneumonia and empyema in England before and after the introduction of PCV7.A population-based time-trend analysis of Hospital Episode Statistics data of children aged15 years admitted to all NHS hospitals in England, with a primary diagnosis of bacterial pneumonia and empyema from 1997 to 2008 was performed. Annual crude and age-sex standardised hospital admission rates for bacterial pneumonia and empyema were calculated.Admission rates for bacterial pneumonia and empyema increased from 1997 to 2006, then declined to 2008. Bacterial pneumonia rates decreased to 1079 (95% CI 1059 to 1099) per million children and empyema rates decreased to 14 (95% CI 11 to 16) per million children. The RR for bacterial pneumonia admissions was 1.19 (95% CI 1.16 to 1.22) in 2006 compared with 2004 and 0.81 (95% CI 0.79 to 0.83) in 2008 compared with 2006. For empyema, the corresponding RRs were 1.77 (95% CI 1.38 to 2.28) in 2006 compared with 2004 and 0.78 (95% CI 0.62 to 0.98) in 2008 compared with 2006.Childhood bacterial pneumonia and empyema admission rates were increasing prior to 2006 and decreased by 19% and 22% respectively between 2006 and 2008, following the introduction of the PCV7 pneumococcal conjugate vaccination to the national childhood immunisation programme. |
Databáze: | OpenAIRE |
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