The Mothers, Infants, and Lactation Quality (MILQ) Study: A Multi-Center Collaboration
| Autor: | Sophie E Moore, Setareh Shahab-Ferdows, Lindsay H. Allen, Maria Andersson, Kamilla G. Eriksen, Gilberto Kac, Andrew M. Doel, M Munirul Islam, Kim F. Michaelsen, Fanta Njie, Janet M Peerson, Daniela de Barros Mucci, Erica G. Barros, Daniela Hampel, Sophie Hilario Christensen, Farhana K Keya |
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| Rok vydání: | 2021 |
| Předmět: |
macronutrients
Clinical Trials and Supportive Activities Medicine (miscellaneous) Reproductive health and childbirth Urine AcademicSubjects/MED00060 Clinical Research Environmental health Lactation Faculty of Science medicine Center (algebra and category theory) Nutrition Pediatric Pregnancy Nutrition and Dietetics business.industry human milk reference values Anthropometry Composistion Micronutrient medicine.disease Good Health and Well Being medicine.anatomical_structure composition Maternal and Pediatric Nutrition micronutrients Reference values Research Methodology/Study Design business Postpartum period Food Science |
| Zdroj: | Current developments in nutrition, vol 5, iss 10 Allen, L H, Hampel, D, Shahab-Ferdows, S, Andersson, M, Barros, E, Doel, A M, Eriksen, K G, Christensen, S H, Islam, M, Kac, G, Keya, F K, Michaelsen, K F, de Barros Mucci, D, Njie, F, Peerson, J M & Moore, S E 2021, ' The Mothers, Infants, and Lactation Quality (MILQ) Study: A multi-center collaboration ', Current Developments in Nutrition, vol. 5, no. 10, nzab116 . https://doi.org/10.1093/cdn/nzab116 Current Developments in Nutrition |
| ISSN: | 2475-2991 |
| Popis: | Little valid information is available on human milk nutrient concentrations, especially for micronutrients (MNs), and there are no valid reference values (RVs) across lactation. In this multi-center collaborative study, RVs will be established for human milk nutrients across the first 8.5 mo postpartum. Well-nourished, unsupplemented women in Bangladesh, Brazil, Denmark, and The Gambia (n = 250/site) were recruited during the third trimester of pregnancy. Milk, blood, saliva, urine, and stool samples from mothers and their infants are collected identically at 3 visits (1–3.49, 3.5–5.99, 6.0–8.49 mo postpartum). Milk analyses include macronutrients, selected vitamins, trace elements and minerals, iodine, metabolomics, amino acids, human milk oligosaccharides, and bioactive peptides. We measure milk volume; maternal and infant diets, anthropometry, and morbidity; infant development, maternal genome, and the infant and maternal microbiome. RVs will be constructed based on methods for the WHO Child Growth Standards and the Intergrowth-21st Project. This trial was registered at clinical trials.gov as NCT03254329. This article describes the protocol for an international study of human milk composition that will enable the construction of reference values for milk nutrient concentrations during lactation. |
| Databáze: | OpenAIRE |
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