Intravenous AAV8 Encoding Urocortin-2 Increases Function of the Failing Heart in Mice
| Autor: | Julieta Diaz-Juarez, Atsushi Miyanohara, Dimosthenis Giamouridis, H. Kirk Hammond, Young Chul Kim, Jorge Suarez, Wolfgang H. Dillmann, Jay Parikh, Mei Hua Gao, Stephen Hightower, N. Chin Lai, Tracy Guo |
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| Rok vydání: | 2015 |
| Předmět: |
Cardiac function curve
Male medicine.medical_specialty Corticotropin-Releasing Hormone Genetic Vectors Blood Pressure Ventricular Function Left Electrocardiography Heart Rate Internal medicine Heart rate Genetics Cyclic AMP Medicine Animals Humans Myocardial infarction Molecular Biology Urocortins Research Articles Urocortin Heart Failure Ejection fraction medicine.diagnostic_test business.industry Genetic Therapy Dependovirus medicine.disease Cyclic AMP-Dependent Protein Kinases 3. Good health Mice Inbred C57BL Blood pressure Liver Heart failure Injections Intravenous Cardiology Molecular Medicine Calcium business |
| Zdroj: | Human Gene Therapy |
| ISSN: | 1557-7422 |
| Popis: | Urocortin-2 (UCn2) peptide infusion increases cardiac function in patients with heart failure, but chronic peptide infusion is cumbersome, is costly, and provides only short-term benefits. Gene transfer would circumvent these shortcomings. We previously showed that a single intravenous (IV) injection of AAV8.UCn2 increases plasma UCn2 and left ventricular (LV) systolic and diastolic function for at least 7 months in normal mice. Here we test the hypothesis that IV delivery of AAV8.UCn2 increases function of the failing heart. Myocardial infarction (MI, by coronary ligation) was used to induce heart failure, which was assessed by echocardiography 3 weeks after MI. Mice with LV ejection fraction (EF) |
| Databáze: | OpenAIRE |
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