GRP78 Protein Expression as Prognostic Values in Neoadjuvant Chemoradiotherapy and Laparoscopic Surgery for Locally Advanced Rectal Cancer
| Autor: | Kang-Moon Lee, Sung Hwan Kim, Hyun-Min Cho, Byoung Yong Shim, Hee Yeon Lee, Ji-Han Jung, Hyung-Jin Kim, Jong Hoon Lee |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Oncology Laparoscopic surgery Cancer Research medicine.medical_specialty Colorectal cancer medicine.medical_treatment Leucovorin Locally advanced GPI-Linked Proteins Gastroenterology Protein expression Internal medicine Biomarkers Tumor medicine Humans Endoplasmic Reticulum Chaperone BiP Heat-Shock Proteins Aged Rectal Neoplasms business.industry Chemoradiotherapy Adjuvant Molecular chaperone GRP78 Middle Aged Prognosis medicine.disease Neoadjuvant Therapy Neoplasm Proteins Log-rank test Endoplasmic reticulum stress Intercellular Signaling Peptides and Proteins Immunohistochemistry Original Article Female Laparoscopy Fluorouracil Bolus (digestion) business TDGF1 protein Neoadjuvant chemoradiotherapy |
| Zdroj: | Cancer Research and Treatment : Official Journal of Korean Cancer Association |
| ISSN: | 2005-9256 1598-2998 |
| DOI: | 10.4143/crt.2014.121 |
| Popis: | Purpose We investigated the relationships between biomarkers related to endoplasmic reticulum stress proteins (glucose-regulated protein of molecular mass 78 [GRP78] and Cripto-1 [teratocarcinoma-derived growth factor 1 protein]), pathologic response, and prognosis in locally advanced rectal cancer. Materials and methods All clinical stage II and III rectal cancer patients received 50.4 Gy over 5.5 weeks, plus 5-fluorouracil (400 mg/m(2)/day) and leucovorin (20 mg/m(2)/day) bolus on days 1 to 5 and 29 to 33, and surgery was performed at 7 to 10 weeks after completion of all therapies. Expression of GRP78 and Cripto-1 proteins was determined by immunohistochemistry and was assessed in 101 patients with rectal cancer treated with neoadjuvant chemoradiotherapy (CRT). Results High expression of GRP78 and Cripto-1 proteins was observed in 86 patients (85.1%) and 49 patients (48.5%), respectively. Low expression of GRP78 protein was associated with a significantly high rate of down staging (80.0% vs. 52.3%, respectively; p=0.046) and a significantly low rate of recurrence (0% vs. 33.7%, respectively; p=0.008) compared with high expression of GRP78 protein. Mean recurrence-free survival according to GRP78 expression could not be estimated because the low expression group did not develop recurrence events but showed a significant correlation with time to recurrence, based on the log rank method (p=0.007). GRP78 also showed correlation with overall survival, based on the log rank method (p=0.045). Conclusion GRP78 expression is a predictive and prognostic factor for down staging, recurrence, and survival in rectal cancer patients treated with 5-fluorouracil and leucovorin neoadjuvant CRT. |
| Databáze: | OpenAIRE |
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