Metastatic retroperitoneal tumor from a non-functional neuroendocrine neoplasia of the left ethmoid-nose-orbitary region: case report and short review of literature
| Autor: | Carlo Cataldi, Silvia Trombetta, Roberto Mazzarella-Farao, Pierluigi Marini, Pietro Fransvea, Francesco Scocchera, Gaetano Poillucci, Massimo Capaldi, Saverio Cerasari |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Larynx
DCG dense core granules Pathology medicine.medical_specialty APUD amine precursor uptake decarboxylation metastatic neuroendocrine tumor CT computer tomografy PET positrone emission tomography nose-orbital region MEN multiple endocrine neoplasia Neuroendocrine tumors Article WHO World Health Organization Metastasis 03 medical and health sciences Retroperitoneal tumor NSE neuron specific enolase 0302 clinical medicine NENs NEN NeuroEndocrine Neoplasm Medicine Neoplasm NET NeuroEndocrine Tumor Nose Neuroendocrine neoplasia FLT FLuoroThymidine business.industry food and beverages Retroperitoneal metastasis NETs HPF high-power field FDG FluoroDeoxyGlucose medicine.disease MANEC Mixed AdenoNeuroEndocrine Carcinoma medicine.anatomical_structure NEC NeuroEndocrine Carcinoma MRI magnetic resonance imagine 030220 oncology & carcinogenesis retroperitoneal metastasis BINT biologically inactive neuroendocrine tumor 030211 gastroenterology & hepatology Surgery business |
| Zdroj: | International Journal of Surgery Case Reports |
| Popis: | Highlights • NENs are rare tumors with extremely variable behavior: they are difficult to diagnose, especially if biologically inactive. • NENs can originate from any epithelial organ and present unusual metastases. • NEN surgery is a valid treatment and a necessary tool for correct diagnosis. • NEN classification is evolving and being discussed. • Careful collection of anamnestic data and a correct analysis of patients’ symptoms can be a valuable resource. Introduction NeuroEndocrine Neoplasms (NENs) are rare and can originate from any epithelial organ. We describe a very rare case of retroperitoneal metastasis from a non-functioning neuroendocrine tumor of the ethmoid region and focus on the various issues related to NENs, from their nosological classification up to the most recent acquisitions in the diagnostic and therapeutic field. Presentation of case A woman presented with a mass in the right retroperitoneal area that infiltrated liver and kidney. The anamnestic data showed a previous undifferentiated small cell tumor of the left ethmoid-nasal-orbital region. The mass was removed surgically and the definitive histological examination revealed a non-functioning undifferentiated malignant small cell neoplasm. Discussion NENs represent a chapter of oncology whose systematization remains difficult. The lack of hormonal syndrome in Biologically Inactive Neuroendocrine Tumors (BINTs) may delay the diagnosis. Clinical manifestations relate to the size and location of the neoplasm. Small cell NeuroEndocrine Carcinoma (NEC) of the ethmoid-nose-orbital region is an extremely rare occurrence and generally the most frequent metastatic localization is represented by the larynx. Conclusion This case highlights the contradictions typical of NENs and only new scientific acquisitions in the histopathological field can help us in the future. Surgery remains the only possibility of treatment and diagnosis of large masses of inactive NENs. This is the only case in the world of metastasis from NEC of the nose-orbital region in the retroperitoneum. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|