| Autor: |
Yanxin Chen, Yongzhi Zheng, Yunda Hong, Jingjing Wen, Jiazheng Li, Yan Huang, Yi Chen, Xiaoyun Zheng, Ting Yang, Yangqi Xu, Jing Zheng, Jianda Hu |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of leukocyte biologyREFERENCES. 112(3) |
| ISSN: |
1938-3673 |
| Popis: |
The prognosis of acute lymphoblastic leukemia (ALL) in adults is inferior to that in children. Hence, ALL remains challenging to cure in the adult population. Aberrant genetic alterations have been observed in ALL, although the patterns of differential gene alterations in adult and pediatric ALL have not been comprehensively determined on a genome-wide scale. We investigated the biologic differences in genomic profiles between adults (n = 64) and children (n = 54) with ALL and relationship between genomic heterogeneity and prognosis. The 2 populations showed similar common mutation types but an increased prevalence of genetic alterations in adult ALL. The median numbers of gene mutations were 17 (range: 1–53) and 4.5 (range: 1–19) per sample in adult and pediatric ALL, respectively (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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