The immunopathology of Mooren's ulcer
| Autor: | C. Stephen Foster, Mathea R. Allansmith, Kenneth R. Kenyon, Dirk K. Greineder, Jack V. Greiner, Beth R. Friedland |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty medicine.medical_treatment Cornea Corneal Transplantation Immunologic Technique Stroma Immunopathology medicine Humans Corneal Ulcer Corneal transplantation Immunosuppression Therapy business.industry Immunosuppression corneal ulcer medicine.disease digestive system diseases Ophthalmology medicine.anatomical_structure Immunologic Techniques Methotrexate business medicine.drug |
| Zdroj: | American journal of ophthalmology. 88(2) |
| ISSN: | 0002-9394 |
| Popis: | In a 42-year-old man with bilateral severe Mooren's ulcers, results of immunologic studies were normal, with the exception of an in vitro blastogenic response of the patient's lymphocytes to corneal stroma. The histologic studies revealed vast numbers of vacuolated neutrophils with intracytoplasmic phagosomes in and about the ulcerating cornea. Although the progression of ulceration was initially unaltered by surgical and pharmacologic trials, systemic immunosuppression with methotrexate may have prevented ulceration of the lamellar tectonic graft. |
| Databáze: | OpenAIRE |
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