Clinical aspects of neurointestinal disease: Pathophysiology, diagnosis, and treatment
| Autor: | Roberto De Giorgio, T. B. Karunaratne, Nikhil Thapar, Allan M. Goldstein |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Molecular Biology Developmental Biology Cell Biology Disease Biology Enteric Nervous System NO 03 medical and health sciences Humans Chagas Disease Hirschsprung Disease Slow transit constipation Extramural Intestinal Pseudo-Obstruction International working group Pathophysiology Chronic intestinal pseudoobstruction Esophageal Achalasia Gastrointestinal Tract Functional integrity 030104 developmental biology Enteric nervous system Constipation Neuroscience |
| Zdroj: | Developmental Biology. 417:217-228 |
| ISSN: | 0012-1606 |
| DOI: | 10.1016/j.ydbio.2016.03.032 |
| Popis: | The enteric nervous system (ENS) is involved in the regulation of virtually all gut functions. Conditions referred to as enteric neuropathies are the result of various mechanisms including abnormal development, degeneration or loss of enteric neurons that affect the structure and functional integrity of the ENS. In the past decade, clinical and molecular research has led to important conceptual advances in our knowledge of the pathogenetic mechanisms of these disorders. In this review we consider ENS disorders from a clinical perspective and highlight the advancing knowledge regarding their pathophysiology. We also review current therapies for these diseases and present potential novel reparative approaches for their treatment. |
| Databáze: | OpenAIRE |
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