Expression of Snail2 in long bone osteosarcomas correlates with tumour malignancy
| Autor: | Joanna S. Price, Steve Allen, Ken C. Smith, Imelda M. McGonnell, Judith Hargreaves, Amir S. Sharili |
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| Jazyk: | angličtina |
| Předmět: |
Male
musculoskeletal diseases Pathology medicine.medical_specialty Cancer Research Long bone Snail2 Bone Neoplasms Core Binding Factor Alpha 1 Subunit Disease Biology Malignancy Metastasis 03 medical and health sciences Tumor grade Prognostic marker Dogs 0302 clinical medicine Runx2 Cell Line Tumor medicine Animals Humans Neoplasm Metastasis 030304 developmental biology Osteosarcoma 0303 health sciences General Medicine medicine.disease Rats RUNX2 medicine.anatomical_structure 030220 oncology & carcinogenesis Female Snail Family Transcription Factors Sarcoma Research Article Transcription Factors |
| Zdroj: | Tumour Biology |
| ISSN: | 1010-4283 |
| DOI: | 10.1007/s13277-010-0146-1 |
| Popis: | Snail2 is a marker of malignancy in epithelial tumours; however, in sarcomas, it is not known if this protein is present. Here we examine the expression of Snail2 in one type of sarcoma, osteosarcoma, and explore its relationship to tumour grade, subtype and anatomical location in cases of long bone and cranial bone osteosarcoma. Long bone osteosarcomas typically have a much greater metastatic capability and a poorer prognosis. We find that Snail2 is expressed in the three main subtypes of long bone osteosarcoma—osteoblastic, chondroblastic and fibroblastic. Regression analysis showed that Snail 2 expression was statistically correlated with tumour grade (p = 0.014) in all of these subtypes. Snail2 was only expressed in high-grade cranial bone osteosarcomas, suggesting a link between Snail2 expression and metastasis. This is the first time Snail2 has been associated with any sarcoma, and this study shows that Snail2 may be a useful prognostic marker for this disease. Electronic supplementary material The online version of this article (doi:10.1007/s13277-010-0146-1) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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