Single-photon emission computed tomography/computed tomography in lung cancer and malignant lymphoma

Autor: Orazio Schillaci
Rok vydání: 2006
Předmět:
Lung Neoplasms
Technology Assessment
Biomedical
Biomedical
Lymphoma
gallium 67
single photon emission computer tomography
technetium 99m
Single-photon emission computed tomography
computer assisted tomography
rituximab
Computer-Assisted
Technology Assessment
drug uptake
depreotide tc 99m
gallium citrate ga 67
iodine 131
pentetreotide in 111
tetrofosmin
yttrium 90
cancer grading
cancer staging
clinical trial
disease severity
dosimetry
drug accumulation
drug distribution
drug mechanism
human
lung cancer
lymphoma
review
Equipment Design
Humans
Image Enhancement
Image Interpretation
Computer-Assisted
Subtraction Technique
Tomography
Emission-Computed
Single-Photon
Tomography
X-Ray Computed
Tomography
medicine.diagnostic_test
Primary tumor
X-Ray Computed
Positron emission tomography
Radiology
Preclinical imaging
medicine.medical_specialty
Settore MED/50 - Scienze Tecniche Mediche Applicate
Spect imaging
medicine
Radiology
Nuclear Medicine and imaging
Image Interpretation
PET-CT
business.industry
medicine.disease
Radionuclide therapy
Emission-Computed
business
Nuclear medicine
Emission computed tomography
Single-Photon
Zdroj: Seminars in nuclear medicine. 36(4)
ISSN: 0001-2998
Popis: In nuclear oncology, despite the fast-growing diffusion of 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET), single-photon emission computed tomography (SPECT) studies can still play an useful clinical role in several applications. The main limitation of SPECT imaging with tumor-seeking agents is the lack of the structural delineation of the pathologic processes they detect; this drawback sometimes renders SPECT interpretation difficult and can diminish its diagnostic accuracy. Fusion with morphological studies can overcome this limitation by giving an anatomical map to scintigraphic data. In the past, software-based fusion of independently performed SPECT and CT images proved to be time-consuming and impractical for routine use. The recent development of dual-modality integrated imaging systems that provide functional (SPECT) and anatomical (CT) images in the same scanning session, with the acquired images coregistered by means of the hardware, has opened a new era in this field. The first reports indicate that SPECT/CT is very useful in cancer imaging because it is able to provide further information of clinical value in several cases. In SPECT, studies of lung cancer and malignant lymphomas using different radiopharmaceutical, hybrid images are of value in providing the correct localization of tumor sites, with a precise detection of the involved organs, and the definition of their functional status, and in allowing the exclusion of disease in sites of physiologic tracer uptake. Therefore, in lung cancer and lymphomas, hybrid SPECT/CT can play a role in the diagnosis of the primary tumor, in the staging of the disease, in the follow-up, in the monitoring of therapy, in the detection of recurrence, and in dosimetric estimations for target radionuclide therapy.
Databáze: OpenAIRE
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