Prevalence of group A β-hemolytic streptococcal throat carriage and prospective pilot surveillance of streptococcal sore throat in Ugandan school children
| Autor: | Andrea Beaton, Ian W Hovis, Emmy Okello, Alyssa DeWyer, Aileen Y. Chang, Chris T. Longenecker, Joselyn Rwebembera, Craig Sable, Jennipher Kamarembo, Asha C. Bowen, James B. Dale, Mark E Engel, Twalib Aliku, Freddie Bwanga, Jonathan R. Carapetis, Amy Scheel, Allison R. Webel, Rachel Sarnacki |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Male medicine.medical_specialty Adolescent Scarlet Fever Streptococcus pyogenes 030106 microbiology Acute Pharyngitis medicine.disease_cause lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Throat Internal medicine Streptococcal Infections otorhinolaryngologic diseases medicine Sore throat Prevalence Humans Uganda lcsh:RC109-216 030212 general & internal medicine Prospective Studies Prospective cohort study business.industry Streptococcus Pharyngitis General Medicine medicine.disease Infectious Diseases medicine.anatomical_structure Carriage Cross-Sectional Studies Rheumatic fever Pharynx Female medicine.symptom Rheumatic Fever business |
| Zdroj: | International Journal of Infectious Diseases, Vol 93, Iss, Pp 245-251 (2020) |
| ISSN: | 1201-9712 |
| Popis: | Objectives: Group A β-hemolytic Streptococcus (GAS), also known as Streptococcus pyogenes, is responsible for an annual 600 million cases of acute pharyngitis globally, with 92% of those infections occurring in low-resource settings. Further knowledge of the acute streptococcal pharyngitis burden in low-resource settings is essential if serious post-streptococcal complications – rheumatic fever (RF) and its long-term sequel rheumatic heart disease (RHD) – are to be prevented. Methods: Two studies were conducted in school-aged children (5–16 years): a cross-sectional study of streptococcal pharyngeal carriage followed by a prospective cohort study of streptococcal sore throat over 4 weeks from March to April 2017. Results: The cross-sectional study revealed an overall prevalence of GAS carriage of 15.9% (79/496, 95% confidence interval 12.8–19.5%). Among 532 children enrolled in the prospective cohort study, 358 (67%) reported 528 sore throats, with 221 (41.1%) experiencing at least one GAS-positive sore throat. The overall GAS-positive rate for sore throat was 41.8% (221/528). Conclusions: The GAS pharyngeal carriage rates seen in Uganda (15.9%, 95% confidence interval 12.8–19.5%) are higher than the most recent pooled results globally, at 12% (range 6–28%). Additionally, pilot data suggest a substantially higher percentage of sore throat that was GAS-positive (41.8%) compared to pooled global rates when active recruitment is employed. Keywords: Group A β-hemolytic Streptococcus, Uganda, Rheumatic fever, Rheumatic heart disease |
| Databáze: | OpenAIRE |
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