A case of acanthosis nigricans in a HIV-infected patient

Autor:	Marcello Di Paolo, Ludovica De Vincentiis, Giuseppe Soda, Alessandra Iacovelli, Ivano Mezzaroma, Paolo Palange
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	0301 basic medicine Male medicine.medical_specialty Anti-HIV Agents Acanthosis nigricans Physical examination Context (language use) HIV-1 infection lcsh:Infectious and parasitic diseases Lesion 03 medical and health sciences 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) Case report medicine Humans lcsh:RC109-216 030212 general & internal medicine acanthosis nigricans antiretroviral therapy case report hiv-1 infection metabolic syndrome Acquired Immunodeficiency Syndrome medicine.diagnostic_test business.industry Middle Aged medicine.disease 030112 virology Dermatology Metabolic syndrome Antiretroviral therapy Pneumonia Infectious Diseases Etiology HIV-1 Virus Activation medicine.symptom business
Zdroj:	BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-4 (2020) BMC Infectious Diseases
ISSN:	1471-2334
DOI:	10.1186/s12879-020-05089-1
Popis:	Background To date, very little information is available concerning the relationship between acanthosis nigricans (AN) and infection with human immunodeficiency virus type 1 (HIV-1). Case presentation Herein, we report the case of a middle-aged man admitted for fever and progressively worsening dyspnea in the context of an opportunistic pneumonia and firstly diagnosed with acquired immunodeficiency syndrome (AIDS). At the time of diagnosis, physical examination revealed the presence of a palpable, hyperpigmented skin lesion on the left areola with surface desquamation and velvety texture consistent with AN. Of note, the most common primary etiologies related to AN were excluded and the complete regression of the skin lesion was observed once antiretroviral therapy was started. Conclusion This is the second report of AN found in patients with AIDS and apparently responsive to prolonged antiretroviral treatment. Possible explanations of this association are still not completely understood, probably related to virus-induced changes in lipid metabolism. Our experience suggests that HIV testing should always be considered in the setting of apparently idiopathic AN.
Databáze:	OpenAIRE
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