Protein delivery into cells using inorganic nanoparticle–protein supramolecular assemblies
| Autor: | Joseph Hardie, Federica Scaletti, Vincent M. Rotello, Yi-Wei Lee, Moumita Ray, David C. Luther |
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| Rok vydání: | 2018 |
| Předmět: |
Macromolecular Substances
Chemistry Endosome Cancer therapy Supramolecular chemistry Proteins Nanoparticle Nanotechnology 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Article Cell Line 0104 chemical sciences Proteins metabolism Humans Nanoparticles 0210 nano-technology |
| Zdroj: | Chemical Society Reviews. 47:3421-3432 |
| ISSN: | 1460-4744 0306-0012 |
| DOI: | 10.1039/c8cs00008e |
| Popis: | The delivery of proteins into cells is a potential game changer for a wide array of therapeutic purposes, including cancer therapy, immunomodulation and treatment of inherited diseases. In this review, we present recently developed nanoassemblies for protein delivery that utilize strategies that range from direct assembly, encapsulation and composite formation. We will discuss factors that affect the efficacy of nanoassemblies for delivery from the perspective of both nanoparticles and proteins. Challenges in the field, particularly achieving effective cytosolar protein delivery through endosomal escape or evasion are discussed. |
| Databáze: | OpenAIRE |
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