Evaluation of Antioxidant and Immunity-Enhancing Activities of Sargassum pallidum Aqueous Extract in Gastric Cancer Rats
| Autor: | Tienan Bi, Shen-Kang Zhou, Ruili Zhang, Wen Da Luo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Antioxidant antioxidant medicine.medical_treatment Pharmaceutical Science Pharmacology Antioxidants Analytical Chemistry law.invention Lipid peroxidation chemistry.chemical_compound law Malondialdehyde Drug Discovery Sargassum pallidum Catalase Glutathione Sargassum pallidum aqueous extract IL-2 IL-4 TNF-α medicine.anatomical_structure Chemistry (miscellaneous) Molecular Medicine Tumor necrosis factor alpha Biology Article Microbiology Immunity Stomach Neoplasms Gastric mucosa medicine Animals Physical and Theoretical Chemistry Rats Wistar Glutathione Peroxidase Plant Extracts Superoxide Dismutase Interleukins Organic Chemistry Sargassum Cancer Water medicine.disease biology.organism_classification Rats chemistry Gastric Mucosa Phytotherapy |
| Zdroj: | Molecules; Volume 17; Issue 7; Pages: 8419-8429 Molecules |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules17078419 |
| Popis: | The effect of Sargassum pallidum (brown seaweed) aqueous extract on the immunity function and antioxidant activities in was studied gastric cancer rats. Treatment with Sargassum pallidum aqueous extract at oral doses 400, 600 or 800 mg/kg body weight was found to provide a dose-dependent protection against N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced immunity damage and oxidative injury by enhancing serum interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-10 (IL-10) levels, decreasing interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α) levels, preserving normal antioxidant enzymes activities, and by inhibiting lipid peroxidation in gastric mucosa. It can be concluded that Sargassum pallidum aqueous extract may enhance the immunity and antioxidant activities in gastric cancer rats. |
| Databáze: | OpenAIRE |
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