Expanded CURB-65: A new score system predicts severity of community-acquired pneumonia with superior efficiency
| Autor: | Xue Jie Wu, Feng Xu, Alessio Farcomeni, Ling Xian Shi, Jin Liang Liu, Ying Li Zhao, Marco Falcone, Hui Zhou, Mario Venditti, Rui Qing Lu, Xiao Jun Dong, Shu Ya Luo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
pneumonia hcap
medicine.medical_specialty multidisciplinary pneumonia delivery of health care Article 03 medical and health sciences 0302 clinical medicine Community-acquired pneumonia Internal medicine Severity of illness medicine In patient 030212 general & internal medicine Multidisciplinary business.industry medicine.disease CURB-65 Surgery Pneumonia Increased risk Blood pressure 030228 respiratory system Cohort business Settore SECS-S/01 - Statistica |
| Zdroj: | Scientific Reports |
| Popis: | Aim of this study was to develop a new simpler and more effective severity score for community-acquired pneumonia (CAP) patients. A total of 1640 consecutive hospitalized CAP patients in Second Affiliated Hospital of Zhejiang University were included. The effectiveness of different pneumonia severity scores to predict mortality was compared, and the performance of the new score was validated on an external cohort of 1164 patients with pneumonia admitted to a teaching hospital in Italy. Using age ≥ 65 years, LDH > 230 u/L, albumin 9/L, confusion, urea > 7 mmol/L, respiratory rate ≥ 30/min, low blood pressure, we assembled a new severity score named as expanded-CURB-65. The 30-day mortality and length of stay were increased along with increased risk score. The AUCs in the prediction of 30-day mortality in the main cohort were 0.826 (95% CI, 0.807–0.844), 0.801 (95% CI, 0.781–0.820), 0.756 (95% CI, 0.735–0.777), 0.793 (95% CI, 0.773–0.813) and 0.759 (95% CI, 0.737–0.779) for the expanded-CURB-65, PSI, CURB-65, SMART-COP and A-DROP, respectively. The performance of this bedside score was confirmed in CAP patients of the validation cohort although calibration was not successful in patients with health care-associated pneumonia (HCAP). The expanded CURB-65 is objective, simpler and more accurate scoring system for evaluation of CAP severity, and the predictive efficiency was better than other score systems. |
| Databáze: | OpenAIRE |
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