Experimental Schistosoma japonicum-induced pulmonary hypertension
| Autor: | Biruk Kassa, Michael H. Lee, Rahul Kumar, Claudia Mickael, Linda Sanders, Rubin M. Tuder, Margaret Mentink-Kane, Brian B. Graham |
|---|---|
| Přispěvatelé: | Downs, Jennifer A |
| Rok vydání: | 2021 |
| Předmět: |
Inflammation
Hypertension Pulmonary Public Health Environmental and Occupational Health Pulmonary Schistosoma mansoni Biological Sciences Cardiovascular Medical and Health Sciences Schistosoma japonicum Vector-Borne Diseases Mice Rare Diseases Good Health and Well Being Infectious Diseases Tropical Medicine Hypertension Animals Schistosomiasis Digestive Diseases Lung |
| Zdroj: | PLoS neglected tropical diseases, vol 16, iss 4 |
| ISSN: | 1935-2735 |
| Popis: | BackgroundSchistosomiasis, a major cause of pulmonary arterial hypertension (PAH) worldwide, is most clearly described complicating infection by one species,Schistosoma mansoni. Controlled exposure of mice can be used to induce Type 2 inflammation-dependentS.mansonipulmonary hypertension (PH). We sought to determine if another common species,S.japonicum, can also cause experimental PH.MethodsSchistosome eggs were obtained from infected mice, and administered by intraperitoneal sensitization followed by intravenous challenge to experimental mice, which underwent right heart catheterization and tissue analysis.ResultsS.japonicumsensitized and challenged mice developed PH, which was milder than that followingS.mansonisensitization and challenge. The degree of pulmonary vascular remodeling and Type 2 inflammation in the lungs was similarly proportionate. Cross-sensitization revealed that antigens from either species are sufficient to sensitize for intravenous challenge with either egg, and the degree of PH severity depended on primarily the species used for intravenous challenge. Compared to a relatively uniform distribution ofS.mansonieggs,S.japonicumeggs were observed in clusters in the lungs.ConclusionsS.japonicumcan induce experimental PH, which is milder than that resulting from comparableS.mansoniexposure. This difference may result from the distribution of eggs in the lungs, and is independent of which species is used for sensitization. This result is consistent with the clearer association betweenS.mansoniinfection and the development of schistosomiasis-associated PAH in humans. |
| Databáze: | OpenAIRE |
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