The genomic determinants of alcohol preference in mice
| Autor: | Boris Tabakoff, Katherina Kechris, Sanjiv V. Bhave, Wei Hu, Nicholas J. Grahame, Deborah A. Finn, Laura Saba, Paula L. Hoffman |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Candidate gene Alcohol Drinking Quantitative Trait Loci Mice Inbred Strains Biology Quantitative trait locus Polymorphism Single Nucleotide Article Food Preferences Mice Meta-Analysis as Topic Gene expression Genetics Animals Gene Oligonucleotide Array Sequence Analysis Gene Expression Profiling Olfactory tubercle Brain Chromosome Mapping Olfactory bulb Mice Inbred C57BL Gene expression profiling Mice Inbred DBA Orbitofrontal cortex |
| Zdroj: | Mammalian Genome. 19:352-365 |
| ISSN: | 1432-1777 0938-8990 |
| DOI: | 10.1007/s00335-008-9115-z |
| Popis: | Searches for the identity of genes that influence the levels of alcohol consumption by humans and other animals have often been driven by presupposition of the importance of particular gene products in determining positively or negatively reinforcing effects of ethanol. We have taken an unbiased approach and performed a meta-analysis across three types of mouse populations to correlate brain gene expression with levels of alcohol intake. Our studies, using filtering procedures based on QTL analysis, produced a list of eight candidate genes with highly heritable expression, which could explain a significant amount of the variance in alcohol preference in mice. Using the Allen Brain Atlas for gene expression, we noted that the candidate genes' expression was localized to the olfactory and limbic areas as well as to the orbitofrontal cortex. Informatics techniques and pathway analysis illustrated the role of the candidate genes in neuronal migration, differentiation, and synaptic remodeling. The importance of olfactory cues, learning and memory formation (Pavlovian conditioning), and cortical executive function, for regulating alcohol intake by animals (including humans), is discussed. |
| Databáze: | OpenAIRE |
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